Identification of serum exosomal miRNA biomarkers for diagnosis of Rheumatoid arthritis

Gong, Jianmin; Zhang, Xiaoshan; Khan, Adeel; Liang, Jun; Xiong, Tao; Yang, Ping; Li, Zhiyang

doi:10.1016/j.intimp.2024.111604

Cited by 7 publications

(1 citation statement)

References 50 publications

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“… 31 , 32 , 33 , 34 , 35 Similarly, studies have proved that exosomes play an important role as biomarkers in neurodegenerative diseases, 36 , 37 , 38 cardiovascular, 39 , 40 , 41 hepatic, 42 , 43 infectious diseases, 44 , 45 , 46 and autoimmune disease. 47 , 48 , 49 , 50 It is currently recognized as the most promising biomarker in the field of liquid biopsy. 51 , 52 , 53 …”

Section: Introductionmentioning

confidence: 99%

Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases

Xu,

Jiang,

et al. 2024

MedComm

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Exosomes are nanoscale vesicles of cellular origin. One of the main characteristics of exosomes is their ability to carry a wide range of biomolecules from their parental cells, which are important mediators of intercellular communication and play an important role in physiological and pathological processes. Exosomes have the advantages of biocompatibility, low immunogenicity, and wide biodistribution. As researchers’ understanding of exosomes has increased, various strategies have been proposed for their use in diagnosing and treating diseases. Here, we provide an overview of the biogenesis and composition of exosomes, describe the relationship between exosomes and disease progression, and focus on the use of exosomes as biomarkers for early screening, disease monitoring, and guiding therapy in refractory diseases such as tumors and neurodegenerative diseases. We also summarize the current applications of exosomes, especially engineered exosomes, for efficient drug delivery, targeted therapies, gene therapies, and immune vaccines. Finally, the current challenges and potential research directions for the clinical application of exosomes are also discussed. In conclusion, exosomes, as an emerging molecule that can be used in the diagnosis and treatment of diseases, combined with multidisciplinary innovative solutions, will play an important role in clinical applications.

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Section: Introductionmentioning

confidence: 99%

Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases

Xu,

Jiang,

et al. 2024

MedComm

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Applications of plant‐derived extracellular vesicles in medicine

Zhu,

Zhao,

Ding

et al. 2024

MedComm

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Plant‐derived extracellular vesicles (EVs) are promising therapeutic agents owing to their natural abundance, accessibility, and unique biological properties. This review provides a comprehensive exploration of the therapeutic potential of plant‐derived EVs and emphasizes their anti‐inflammatory, antimicrobial, and tumor‐inhibitory effects. Here, we discussed the advancements in isolation and purification techniques, such as ultracentrifugation and size‐exclusion chromatography, which are critical for maintaining the functional integrity of these nanovesicles. Next, we investigated the diverse administration routes of EVs and carefully weighed their respective advantages and challenges related to bioavailability and patient compliance. Moreover, we elucidated the multifaceted mechanisms of action of plant‐derived EVs, including their roles in anti‐inflammation, antioxidation, antitumor activity, and modulation of gut microbiota. We also discussed the impact of EVs on specific diseases such as cancer and inflammatory bowel disease, highlighting the importance of addressing current challenges related to production scalability, regulatory compliance, and immunogenicity. Finally, we proposed future research directions for optimizing EV extraction and developing targeted delivery systems. Through these efforts, we envision the seamless integration of plant‐derived EVs into mainstream medicine, offering safe and potent therapeutic alternatives across various medical disciplines.

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Contribution of PKS+ Escherichia coli to colon carcinogenesis through the inhibition of exosomal miR-885-5p

He,

Ren,

Dong

et al. 2024

Heliyon

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Identification of serum exosomal miRNA biomarkers for diagnosis of Rheumatoid arthritis

Cited by 7 publications

References 50 publications

Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases

Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases

Applications of plant‐derived extracellular vesicles in medicine

Contribution of PKS+ Escherichia coli to colon carcinogenesis through the inhibition of exosomal miR-885-5p

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