Identification of serum microRNA profiles in colon cancer

Hofsli, Eva; Sjursen, Wenche; Prestvik, Wenche S.; Johansen, Julia S.; Rye, Morten; Tranø, Gerd; Wasmuth, Hans H.; Hatlevoll, Ingunn; Thommesen, Liv

doi:10.1038/bjc.2013.121

Cited by 78 publications

(65 citation statements)

References 71 publications

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“…Negative manipulation of oncogenic miRNAs' Up (Wang et al, 2012b, Ng et al, 2009a, Hofsli et al, 2013, Pu et al, 2010 (Hofsli et al, 2013, Zheng et al, 2013) miR-192 Down (Wang et al, 2012b Down (Hofsli et al, 2013) miR-210 Up (Wang et al, 2012b, Hofsli et al, 2013) miR-221 Down (Wang et al, 2012b, Chen et al, 2008, Pu et al, 2010, Hofsli et al, 2013 Up (Chen et al, 2008, Ng et al, 2009a (Ahmed et al, 2009) expression has some similarities with siRNAs in principle and could be achieved through introducing silencing molecules into the cell. Antisense oligonucleotides along with some bearing anchored group, sponge and masking molecules, locked nucleic acid (LNA) are of important miRNA-based therapies.…”

Section: Mirna-based Targeted Crc Therapymentioning

confidence: 99%

MicroRNAs in Colorectal Cancer: from Diagnosis to Targeted Therapy

Orang¹,

Barzegari²

2014

Asian Pacific Journal of Cancer Prevention

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Colorectal cancer (CRC) is one of the major healthcare problems worldwide and its processes of genesis include a sequence of molecular pathways from adenoma to carcinoma. The discovery of microRNAs, a subset of regulatory non-coding RNAs, has added new insights into CRC diagnosis and management. Together with several causes of colorectal neoplasia, aberrant expression of oncomiRs (oncogenic and tumor suppressor miRNAs) in cancer cells was found to be indirectly result in up-or down-regulation of targeted mRNAs specific to tumor promoter or inhibitor genes. The study of miRNAs as CRC biomarkers utilizes expression profiling methods from traditional tissue samples along with newly introduced non-invasive samples of faeces and body fluids. In addition, miRNAs could be employed to predict chemo-and radio-therapy responses and be manipulated in order to alleviate CRC characteristics. The scope of this article is to provide a comprehensive review of scientific literature describing aberrantly expressed miRNAs, and consequently dysregulation of targeted mRNAs along with the potential role of miRNAs in CRC diagnosis and prognosis, as well as to summarize the recent findings on miRNA-based manipulation methods with the aim of advancing in anti-CRC therapies.

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Section: Mirna-based Targeted Crc Therapymentioning

confidence: 99%

MicroRNAs in Colorectal Cancer: from Diagnosis to Targeted Therapy

Orang¹,

Barzegari²

2014

Asian Pacific Journal of Cancer Prevention

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“…The expression of a number of miRNAs has been linked to different cancers and their progression. But contrary to the stool, the origins of these miRNAs and how they arrive in the blood are not yet fully known [129], Still, miRNAs as biomarkers of cancer are being validated and are winding their way toward the clinic.…”

Section: Discussionmentioning

confidence: 99%

Role of MicroRNA Molecules in Colon Cancer Etiology

Ahmed¹

2014

Biol Med

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The biogenesis of micro (mi) RNA suggests that nearly 3% of human genes are encoded for micro (mi) RNAs, and computer predictions indicate that more than 30% of protein coding genes in humans are coded by miRNAs through an imperfect binding to the 3' untranslated region (UTR) of target messenger (m) RNA affecting gene silencing and leading to either transcription repression, or induction of messenger (m) RNA degradation. The expression of several miRNAs in noninvasive body fluids/excrements has been linked to development of colorectal cancer (CRC) and its progression. The majority of miRNA genes are oriented antisense to neighboring genes, and miRNA genes are transcribed by polymerases II and III. The rate of evolution of miRNAs has been very slow, which has permitted morphological innovation by making gene expression specific, a process that permitted the genesis of complex organisms. Bacteria lack true miRNAs. Bioinformatics approaches to predict putative miRNA target genes has been facilitated by finding that miRNA target recognition is partly based on simple sequence complementarity, and exact base pairing between miRNAs and their targets is required only in the first six to eight bases from the 5′ end of the miRNA.

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“…Este trabajo utilizó una herramienta reciente de biotecnología molecular para estudiar el perfil de miRNAs (Castoldi, 2007) en cardiomiocitos aislados expuestos a condiciones de lesión por isquemia y protección por exposición a PCI. Los miRNAs diferencialmente expresados y validados resultan ser molé-culas útiles para anticipar cambios en la expresión de genes importantes en la fisiología de las células cardiacas (Hofsli, 2013). La identificación de miRNAs como potenciales marcadores moleculares que regulen la expresión de genes con propiedades cardiotóxicas o cardioprotectoras y que estén implicados en la fisiopatología de enfermedades cardiovasculares, como en la isquemia y la falla cardiacas, será clave para estudios dirigidos identificar miRNAs con potencial diagnóstico y terapéutico (Baker, 2013).…”

Section: Discussionunclassified

“…Investigaciones recientes en miRNAs han proporcionado un mejor conocimiento sobre el circuito genético integrado, que define procesos celulares básicos como la diferenciación, la viabilidad, la proliferación, la apoptosis, que cuando son alterados pueden asociarse con la patogénesis de enfermedades como el cáncer y las enfermedades cardiovasculares (van Rooij, 2007, Hofsli, 2013. La amplia distribución de este novedoso mecanismo, el cual controla la expresión genética y el paradigma aceptado de que las enfermedades crónicas, como las enfermedades cardiovasculares, son entidades multifactoriales, que resultan de una compleja interacción entre genes y ambiente sugieren un ligamiento entre procesos dependientes de miRNAs y enfermedades crónicas.…”

Section: Introductionunclassified

“…La amplia distribución de este novedoso mecanismo, el cual controla la expresión genética y el paradigma aceptado de que las enfermedades crónicas, como las enfermedades cardiovasculares, son entidades multifactoriales, que resultan de una compleja interacción entre genes y ambiente sugieren un ligamiento entre procesos dependientes de miRNAs y enfermedades crónicas. De hecho, ya se ha demostrado la expresión alterada de miRNAs en el proceso tumorigénico (Babashah, 2011, Hofsli, 2013.…”

Section: Introductionunclassified

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Preacondicionamiento isquémico en cardiomiocitos ventriculares aislados. Identificación y expresión de algunos microRNAs asociados

Gómez-Grosso

2014

Rev. Acad. Colomb. Cienc. Ex. Fis. Nat.

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RESUMENGómez-Grosso L.A.: Preacondicionamiento isquémico en cardiomiocitos ventriculares aislados. Identificación y expresión de algunos microRNAs asociados. Rev. Acad. Colomb. Cienc. 37 (145): [433][434][435][436][437][438][439][440][441][442][443][444][445][446][447] 2013. ISSN 0370-3908.El objetivo de este estudio fue evaluar el preacondicionamiento isquémico, PCI, en cardiomiocitos ventriculares de cobayo adultos individuales y evaluar el perfil de expresión diferencial de microRNAs en estas células. Una supervisión de la morfología, de la actividad metabólica de las células cardíacas individuales aisladas en tiempo real, permite una evaluación de los cambios en la viabilidad de los cardiomiocitos y proporciona evidencia experimental de que el PCI tiene acción citoprotectora directa mediante la promoción de la supervivencia in vitro. La protección cardiaca por PCI asociada con la expresión diferencial de microRNAs específicos en cardiomicitos adultos aislados sugiere que algunos miRNAs están involucrados en lesión y cardioprotección.Palabras clave: cardioprotección, preacondicionamiento, ensayo de MTT, tiempo real, cardiomiocitos, viabilidad, isquemia, Dinitrofenol, Adenosina. ABSTRACTThe aim of this study was to evaluate the ischemic preconditioning, PCI, in single quiescent adult guinea-pig ventricular myocytes and assess the differential expression of microRNAs in these cells. Monitoring of the morphology of the metabolic activity of individual cardiac cells isolated in real time, allows evaluation of changes in the viability of the cardiomyocytes and provides experimental evidence that PCI has direct cytoprotective action by promoting survival in vitro. PCI cardiac protection associated with the differential expression of specific microRNAs in isolated adult cardiomyocytes suggests that miRNAs are involved in some injury and cardioprotection.

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Identification of serum microRNA profiles in colon cancer

Cited by 78 publications

References 71 publications

MicroRNAs in Colorectal Cancer: from Diagnosis to Targeted Therapy

MicroRNAs in Colorectal Cancer: from Diagnosis to Targeted Therapy

Role of MicroRNA Molecules in Colon Cancer Etiology

Preacondicionamiento isquémico en cardiomiocitos ventriculares aislados. Identificación y expresión de algunos microRNAs asociados

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