Identification of sesquiterpene glycosides from Dendrobium nobile and their α-glycosidase and α-amylase inhibitory activities

Abstract

Dendrobium nobile is a traditional Chinese medicine and functional food in China, with anti-aging, immunity-enhancing, glucose-lowering and lipid-lowering health functions. In recent years, the research value of D. nobile has attracted the attention of more and more experts and scholars. Today, phytochemical investigation of the stems of Dendrobium nobile Lindl., led to the isolation of five sesquiterpene glycosides, including dendromoniliside D (1), dendronobiloside A (2), dendronobiloside C (3), dendronobiloside D (4), dendroside G (5) and their α-amylase and α-glycosidase inhibitory activities were also investigated. Among them, dendromoniliside D (1), dendroside G (5) were first isolated from D. nobile. And dendronobiloside A (2) and dendronobiloside C (3) exhibited better inhibitory activity against α-glycosidases, respectively. In the case of α-amylase inhibition, dendroside G (5) has a relatively good effect. These results suggest that sesquiterpene glycosides of D. nobile have potential hypoglycemic activity and deserve further research and development.

Plant terpene specialized metabolism: complex networks or simple linear pathways?

“…As seen for other classes of terpenoids, various sesquiterpenoids have also been found as glycosides. One example is Dendrobium nobile where eight guaiene and eudesmane type sesquiterpene glycosides have been isolated to date ( Tan et al, 2023 ; Zhao et al, 2001 ). The sesquiterpenoid field has not progressed as far as the diterpenoid field when it comes to elucidating long and complex pathways, especially when it comes to acetylated and glycosylated sesquiterpenoids.…”

Transcriptome-based analysis reveals the key genes of sesquiterpene glycosylation in Dendrobium nobile

“…To further predict the glycosylation catalytic activity of candidate UDP-glycosyltransferases on the sesquiterpenes of D. nobile, molecular docking was used to simulate the binding modes between 5 sesquiterpene glycosides and their sapogenins obtained from D. nobile in the previous period (Tan et al, 2023) and 6 candidate UDP-glycosyltransferase including LOC110092682, LOC110093388, LOC110095820, LOC110095859, LOC110096304, and LOC110104141. After docking, the conformational cluster with the lowest binding free energy is shown in the complex of the docked compounds with UDP-glycosyltransferases (Table 2).…”

Effect of environmental factors on the polysaccharide content of Dendrobium officinale

“…D. officinale is firstly recorded in the "Shen Nong's Herbal Classic" (Dong Han Dynasty, and used as traditional Chinese medicine or functional food in China (Yin et al, 2021). In traditional medicine, D. officinale was as a tonic to nourish Yin, clear heat, nourish stomach, and replenish body fluid (Cakova et al, 2017;Shin et al, 2017) and used for various diseases or as beverages (Cakova et al, 2017;Tan et al, 2023). In term of modern pharmacological effects, D. officinale exhibits various pharmacological effects such as enhancing immunity, anti-fatigue, antioxidant, hypoglycemia, hypotension, and others (He et al, 2022;Huang et al, 2019;Lv et al, 2020).…”