Identification of seven psychedelic 2,5‐dimethoxy‐phenylethyl‐amine‐based designer drugs via benchtop ¹H nuclear magnetic resonance spectroscopy

Abstract

The dissemination of spectral information of new psychoactive substances (NPS) acquired on benchtop nuclear magnetic resonance (NMR) spectrometers is of high importance considering the emerging application of such portable and accessible instruments in forensic analyses. Seven members of the 2C-X series (2C-B, 2C-C, 2C-D, 2C-E, 2C-P, 2C-T2, and 2C-T7) of NPS were analyzed via 60 MHz 1 H benchtop NMR spectroscopy and their molecular structural relations are discussed with respect to the observed proton NMR spectra.

Benchtop 19F nuclear magnetic resonance spectroscopy enabled kinetic studies and optimization of the synthesis of carmofur

“…Recent advances in benchtop NMR has facilitated a non-invasive method for real-time monitoring, characterization, and quantification of chemical entities, becoming a practical analytical tool for precise reaction monitoring, condition optimization, and quantitative information on purity and yield directly in the laboratory. Past studies utilize benchtop spectrometers as a low-cost and user-friendly alternative to high-field spectrometers for the heteronuclear characterization of various materials including lignins 17 , fluorinated environmental contaminants 18 , peptide structure 19 , drug identification 20 , and many others. Proton lock capabilities on benchtop spectrometers have allowed heteronuclear NMR-based reaction monitoring without requiring the use of deuterated solvents, which can be financially prohibitive for reactions performed on scale.…”