Identification of Several Different Lineages of Measles Virus

Taylor, Michael J.; Godfrey, Edward; Baczko, K.; Meulen, Volker ter; Wild, T. F.; Rima, B. K.

doi:10.1099/0022-1317-72-1-83

Cited by 125 publications

(76 citation statements)

References 18 publications

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“…From these results we conclude that different MV types exist and that they cocirculate in the population. A similar conclusion has been reached by analysis of the hypervariable part of the MV nucleocapsid (N) gene (Taylor et al, 1991).…”

Section: Maysupporting

confidence: 49%

“…We feel confident that this treatment of the data is correct, because it agrees well with that obtained from the comparison of the N gene sequences of these two viruses. For the N gene an even lower mutation rate of 0.2~ (K. Baczko, unpublished results) was observed and the two viruses are very similar in the hypervariable region of this gene (Taylor et al, 1991). This result suggests that a virus from this lineage may have infected the MIBE patient.…”

Section: Maymentioning

confidence: 77%

See 1 more Smart Citation

Nucleotide sequence of the genes encoding the matrix protein of two wild-type measles virus strains

Baczko

Brinckmann

Pardowitz

et al. 1991

Journal of General Virology

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The nucleotide sequences of the matrix protein (M) genes of two wild-type measles virus (MV) isolates (JM and CM) have been determined and shown to differ in 56 positions; 31 of these differences are located in the non-coding region and 25 in the coding region of the gene. Most (80 %) of the mutations in the coding region are changes to the third base of a codon. A maximum parsimony analysis of the available M gene nucleotide sequences allowed the construction of a tree with at least three lineages or subtypes. One wild-type strain (JM) was very similar to a subacute sclerosing panencephalitis virus strain (case B); the second wild-type strain, CM, showed nucleotide sequence similarity with MV from a case of measles inclusion body encephalitis. Both wild-type virus sequences are distinct from those so far determined for vaccine strains.

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Section: Maysupporting

confidence: 49%

Section: Maymentioning

confidence: 77%

Nucleotide sequence of the genes encoding the matrix protein of two wild-type measles virus strains

Baczko

Brinckmann

Pardowitz

et al. 1991

Journal of General Virology

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“…The virus is monotypic, existing as a single serotype, and infection with one strain appears to provide life-long protection from the disease. With the development of RT/PCR and DNA sequencing techniques, it has become clear that virus isolates vary in their nucleotide sequences, especially in those encoding the last 150 amino acids of the N protein and the entire H protein [29][30][31][32]. At least 22 genotypes exist and these have been grouped into eight clades.…”

Section: Molecular Biology Of the Virusmentioning

confidence: 99%

Morbilliviruses and human disease

Rima

Duprex

2005

The Journal of Pathology

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Morbilliviruses are a group of viruses that belong to the family Paramyxoviridae. The most instantly recognizable member is measles virus (MV) and individuals acutely infected with the virus exhibit a wide range of clinical symptoms ranging from a characteristic mild selflimiting infection to death. Canine distemper virus (CDV) and rinderpest virus (RPV) cause a similar but distinctive pathology in dogs and cattle, respectively, and these, alongside experimental MV infection of primates, have been useful models for MV pathogenesis. Traditionally, viruses were identified because a distinctive disease was observed in man or animals; an infectious agent was subsequently isolated, cultured, and this could be used to recapitulate the disease in an experimentally infected host. Thus, satisfying Koch's postulates has been the norm. More recently, particularly due to the advent of exceedingly sensitive molecular biological assays, many researchers have looked for infectious agents in disease conditions for which a viral aetiology has not been previously established. For these cases, the modified Koch's postulates of Bradford Hill have been developed as criteria to link a virus to a specific disease. Only in a few cases have these conditions been fulfilled. Therefore, many viruses have over the years been definitely and tentatively linked to human diseases and in this respect the morbilliviruses are no different. In this review, human diseases associated with morbillivirus infection have been grouped into three broad categories: (1) those which are definitely caused by the infection; (2) those which may be exacerbated or facilitated by an infection; and (3) those which currently have limited, weak, unsubstantiated or no credible scientific evidence to support any link to a morbillivirus. Thus, an attempt has been made to clarify the published data and separate human diseases actually linked to morbilliviruses from those that are merely anecdotally associated.

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“…brain) or in vitro (i.e. tissue culture) sequences were determined directly by reverse transcription followed by polymerase chain reaction (RT-PCR) on RNA samples extracted from infected tissue or cells using guanidinium isothiocyanate as described by Taylor et al (1991).…”

Section: Methodsmentioning

confidence: 99%

“…Although all six genes of MV appear to vary, though to different extents (Baczko et al, , 1992Rota et al, 1992;Komase et al, 1995), the highest degree of variation is in the C terminus of the N protein and in the H and P proteins. The sequence of the C-terminal 151 amino acids of the N protein has been analysed in 18 strains of MV (Taylor et al, 1991): there was up to 7.2 % divergence in the nucleotide sequence and 10.6% divergence in the amino acid sequence between the most unrelated strains in this region and a number of specific lineage groups of MV were shown to exist. In this report we have used this region to further analyse and group the genotypes of MV.…”

Section: Introductionmentioning

confidence: 99%