2020
DOI: 10.1002/rcm.8582
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Identification of significant protein markers by mass spectrometry after co‐treatment of cells with different drugs: An in vitro survey platform

Abstract: Rationale Understanding drug–drug interactions and predicting the side effects induced by polypharmacy are difficult because there are few suitable platforms that can predict drug–drug interactions and possible side effects. Hence, developing a platform to identify significant protein markers of drug–drug interactions and their associated side effects is necessary to avoid adverse effects. Methods Human liver cells were treated with ethosuximide in combination with cimetidine, ketotifen, metformin, metronidazo… Show more

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“…After centrifugation (13,000 rpm at 4 °C for 20 min), the supernatant was collected and identified through MS. The MS analysis was conducted using a nano-ultra‐performance liquid chromatography (nanoUPLC) system (Waters, Milford, MA, USA) and Synapt High Definition Mass Spectrometry (Waters, Milford, MA, USA), which was similar to the previous study [ 30 ].…”
Section: Methodsmentioning
confidence: 99%
“…After centrifugation (13,000 rpm at 4 °C for 20 min), the supernatant was collected and identified through MS. The MS analysis was conducted using a nano-ultra‐performance liquid chromatography (nanoUPLC) system (Waters, Milford, MA, USA) and Synapt High Definition Mass Spectrometry (Waters, Milford, MA, USA), which was similar to the previous study [ 30 ].…”
Section: Methodsmentioning
confidence: 99%