Identification of Significant Secreted or Membrane-Located Proteins in Laryngeal Squamous Cell Carcinoma

Li, Yan; hu, chunyan; Ji, Yangyang; Zou, Lifen; Zhao, Yang; Zhu, Yi; Wang, Xiaoshen

doi:10.1155/2022/9089397

Cited by 10 publications

(9 citation statements)

References 30 publications

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“…Although the biological function of CLEC11A has not been revealed in CRC, several studies have reported that CLEC11A is significantly associated with the clinical outcomes of cancer patients. [24,25] The prognostic value of CYRAB has been demonstrated in CRC. [26,27] In addition, CYRAB can promote the invasion and metastasis of CRC via the regulation of the epithelial-mesenchymal transition.…”

Section: Discussionmentioning

confidence: 99%

CAF signature predicts the prognosis of colorectal cancer patients: A retrospective study based on bulk RNA sequencing and single-cell RNA sequencing data

Liang

Ji²,

Feng³

et al. 2023

Medicine

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The incidence rate and mortality rate of colorectal cancer (CRC) ranks third and second globally. Cancer-associated fibroblasts (CAFs) are the major constituent of the stromal cells in the tumor microenvironment (TME) and are closely associated with patients’ prognoses. Our study intended to establish a prognostic model for CRC using hallmark genes of CAFs. The expression values of genes and clinicopathological characteristics of patients were enrolled from the cancer genome atlas database as well as the gene expression omnibus database. The single-cell RNA sequencing data were collected and analyzed in the deeply integrated human single-cell omics database and cancer single-cell expression map databases. The ESTIMATE algorithm was applied to access the infiltration levels of immune and stromal cells. The prognostic genes were selected by the Cox regression analysis and the prognostic signature was constructed by the least absolute shrinkage and selection operator algorithm. gene set enrichment analysis was used to explore the enriched gene sets. In this study, based on bulk RNA sequencing and single-cell RNA sequencing data, and we found that more CAFs were infiltrated in the tumor microenvironment and consisted of 3 subtypes. Then we constructed a prognostic signature for CRC using hallmark genes of CAFs and proved that this signature exhibited high values to predict the overall survival of CRC patients in independent training and validating cohorts. Besides, function enrichment analysis revealed that our prognostic model was significantly associated with immune regulation. Further analysis showed that the infiltrated levels of tumor-suppressing immune cells and the expression of higher immune checkpoint genes in CRC tissues were higher in patients with high-risk scores. Furthermore, immunohistochemistry analysis exhibited that these genes in our prognostic signature were markedly upregulated in CRC tissues. We first constructed a signature based on CAFs hallmark genes to predict the survival of CRC patients and further revealed that the tumor-suppressing microenvironment and dysregulated immune checkpoint genes in CRC tissues were partly responsible for the poor prognosis of patients.

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Section: Discussionmentioning

confidence: 99%

CAF signature predicts the prognosis of colorectal cancer patients: A retrospective study based on bulk RNA sequencing and single-cell RNA sequencing data

Liang

Ji²,

Feng³

et al. 2023

Medicine

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“…Global proteome analysis of the mitochondria in Raje cells also identi ed ATAD3B as a potential biomarker of radioresistance (26). CLEC11A is a protein-coding gene that signi cantly participates in the tumor microenvironment and immune cell communication and can predict protein survival in laryngeal squamous cell carcinoma (LSCC) (27). CMTM3 was associated with cell growth and migration in oral squamous cell carcinoma (28) and pancreatic cancer (29) and has roles in the tumor microenvironment and cancer immunotherapy (30).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

Lai,

Wang,

et al. 2023

Preprint

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Background Head and neck cancer (HNC) is the most common worldwide. Radiation therapy plays an important role in treating HNC. MicroRNAs (miRNAs) have been associated with tumor progression and radiosensitivity. However, their mechanisms remain largely unknown, and the evidence remains limited. This study aimed to identify miRNAs associated with the radiosensitivity of head and neck tumor cells, leading to the poor prognosis of patients with HNC receiving radiation therapy. The miRNA expression profiles and clinical information of patients with HNC were obtained from The Cancer Genome Atlas. The miRNAs were identified through an integrated bioinformatics analysis and validated through in vitro and in vivo studies. Results MiR-4776-5p was identified as a radiosensitizer and predictor of the prognosis of patients with HNC receiving radiotherapy. Eleven of 16 genes targeted by miR-4776-5p were found to regulate mechanisms related to radiosensitivity via functional annotation. Conclusion In this study, we identified a miRNA, miR-4776-5p, related to the clinical outcome of patients with HNSC receiving RT alone, which could be potentially selected as a miRNA-based therapeutic target to block radioresistant characteristics and lead to better treatment outcomes for HNC.

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“…A global proteome analysis of the mitochondria in Raje cell also showed ATAD3B as the potential biomarkers of radioresistance [26]. CLEC11A is a protein coding gene significantly participating in tumor microenvironment and immune cells' communication, and can predict the survival of protein in laryngeal squamous cell carcinoma (LSCC) [27] . CMTM3 is not only related to the cell growth and migration of oral squamous cell carcinoma [28] and pancreatic cancer [29], but also has the role in tumor microenvironment and cancer immunotherapy [30].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

Lai

Wang

Lin

et al. 2022

Preprint

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Head and neck cancer is the leading cancer worldwide. Radiation therapy plays important role of treatment for head and neck cancer. MicroRNAs have been shown to be related to tumor progression and radiosensitivity. However, the mechanisms are still largely unknown and evidence are still limited. In the current study, we sought to identify the miRNA related the radiosensi-tivity of head and neck tumor cell, which leading to the disappointed prognosis of patients with head and neck cancer receiving radiation therapy. The miRNA expression profiles and clinical information of patients with head and neck cancer were obtained from The Cancer Genome Atlas. The identification of miRNA was carried out through an integrated bioinformatics analysis. The miRNA identified in previous approach was validated through in vitro and in vivo studies. MiR-4776-5p was finally identified as the role of radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy. 11 of 16 genes targeted by the miR-4776-5p have been discovered to regulate the mechanisms related to radiosensitivity using functional annotation.

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Identification of Significant Secreted or Membrane-Located Proteins in Laryngeal Squamous Cell Carcinoma

Cited by 10 publications

References 30 publications

CAF signature predicts the prognosis of colorectal cancer patients: A retrospective study based on bulk RNA sequencing and single-cell RNA sequencing data

CAF signature predicts the prognosis of colorectal cancer patients: A retrospective study based on bulk RNA sequencing and single-cell RNA sequencing data

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

MicroRNA-4776-5p acts as a radiosensitizer and predicts the prognosis of patients with head and neck cancer receiving radiotherapy

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