Identification of Six Phenylpropanoids from Garlic Skin as Major Antioxidants

Ichikawa, Makoto; Ryu, Kenjiro; Yoshida, Jiro; Ide, Nagatoshi; Kodera, Yoshihisa; Sasaoka, Takashi; Rosén, Robert

doi:10.1021/jf034791a

Cited by 80 publications

(54 citation statements)

References 12 publications

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“…Not only AGE possesses antioxidant activity. In addition, the extract of garlic skins (peels) has the same properties [85]. In this study, the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of garlic skin extract was evaluated.…”

Section: Garlic and Plasma Antioxidant Activitymentioning

confidence: 99%

“…LC-MS and NMR analyses allowed the chemical structures of the isolated constituents to be postulated. The proposed compounds were subsequently synthesized and compared with the constituents in the extract using HPLC-PDA and LC-MS. N-trans-coumaroyloctopamine, N-trans-feruloyloctopamine, guaiacylglycerol-betaferulic acid ether, and guaiacylglycerol-beta-caffeic acid ether were identified as were trans-coumaric acid and transferulic acid [85].…”

Section: Garlic and Plasma Antioxidant Activitymentioning

confidence: 99%

See 1 more Smart Citation

The atherosclerotic heart disease and protecting properties of garlic: contemporary data

Gorinstein¹,

Jastrzębski

Namieśnik

et al. 2007

Molecular Nutrition Food Res

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This article reviews the contemporary data concerning atherosclerosis and protecting properties of garlic. Recent advances in basic science have established a fundamental role for inflammation in mediating all stages of this disease from initiation through progression and, ultimately, the thrombotic complications of atherosclerosis. These new findings provide important links between risk factors and the mechanisms of atherogenesis and garlic properties. Numerous in vitro studies have confirmed the ability of garlic to reduce the parameters of the risk of atherosclerosis: total cholesterol, LDL, triglycerides, oxidized LDL. Bioactive compounds and antioxidant potentials in fresh, cooked, boiled and commercial garlic from different regions are presented, using beta-carotene, 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide (NO), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) with K2S2O8 or MnO2, ferric-reducing/antioxidant power (FRAP), cupric reducing antioxidant capacity (CUPRAC) and others assays for antioxidant status. In vivo studies were reviewed on with garlic and cholesterol supplemented diets. The positive influences of garlic on plasma lipids, proteins, antioxidant activity, and some indices of blood coagulation are dose dependent. Garlic could be a valuable component of atherosclerosis-preventing diets only in optimal doses. Many recently published reports show that garlic possesses plasma lipid-lowering and plasma anticoagulant and antioxidant properties and improves impaired endothelial function.

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Section: Garlic and Plasma Antioxidant Activitymentioning

confidence: 99%

Section: Garlic and Plasma Antioxidant Activitymentioning

confidence: 99%

The atherosclerotic heart disease and protecting properties of garlic: contemporary data

Gorinstein¹,

Jastrzębski

Namieśnik

et al. 2007

Molecular Nutrition Food Res

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show abstract

“…Pant et al [17] found that Arabidopsis thaliana plants contain two phenylpropanoids, cis-sinapic acid and trans-ferulic acid and the fatty acid octadecanoic acid. N-trans-coumaroyloctopamine, N-transferuloyl octopamine, guaiacylglycerol-β-ferulic acid ether, guaiacylglycerol-β-caffeic acid ether, trans-coumaric acid and transferulic acid were identified in garlic skin [22]. While hexadecanoic acid and octadecanoic acid are the fatty acids found in Melissa officinalis [23].…”

Section: Resultsmentioning

confidence: 98%

Phenylpropanoids and Fatty Acids Levels in Roots and Leaves of Datura Stramonium and Datura Innoxia

Rahmoune

Zerrouk

Morsli

et al. 2017

Int J Pharm Pharm Sci

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Objective: The aim of this research was to determine and compare phenylpropanoids and fatty acids composition in two plant species, Datura innoxia and Datura stramonium. Methods:Phenylpropanoids and fatty acids composition in leaves and roots extracted from Datura innoxia and Datura stramonium, grown under greenhouse conditions, was analyzed by gas chromatography-electron impact/time of flight-mass spectrometry (GC-EI/TOF-MS) chromatography techniques. Analyses were carried out at the Max Planck Institute for Molecular Plant Physiology of Golm (Germany). Results:We revealed that Datura stramonium (DS) contains hydroxy-hexanedioic acid while hexanoic acid was found in Datura innoxia (DI). Also, two fatty acids are common to both Datura species, hexadecanoic acid and octadecanoic acid, with an almost equal rate between leaves and roots. However, phenylpropanoids composition revealed eight compounds; luteolin, quercetin, trans-caffeic acid, trans-ferulic acid, cis-caffeic acid, cis-4-hydroxy-cinnamic acid, trans-4-hydroxy-cinnamic acid and trans-sinapic acid in DI. However, in DS, five compounds were detected: luteolin, quercetin, trans-caffeic acid, trans-ferulic acid and dihydroferulic acid. Also in both Datura species, phenylpropanoids concentration in leaves was significantly higher than in the roots. Conclusion:Our results showed a difference in phenylpropanoids and fatty acids compositions between the two Datura species, with a significantly higher concentration of phenylpropanoids in Datura innoxia than in Datura stramonium

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“…Many of the chemical constituents present in Allium sativum (garlic) are known (Amagase, 2006). From the garlic skin, the part used in 'Tira-capeta', were isolated phenylpropanoids (Ichikawa et al, 2003(Ichikawa et al, , 2006 and flavonoids (Stajner et al, 2006). Of the two remaining plants, Anemopaegma arvense ('alecrimdo-norte') and Hyptis cana ('hortelã-da-várzea'), there are no phytochemical data in the literature, but we suppose that they possess tannins, flavonoids and saponins, since they are the major constituents of ETC.…”

Section: Catalepsy Testmentioning

confidence: 99%

Preliminary investigation of the central nervous system effects of ‘Tira‐capeta’ (Removing the Devil), a cigarette used by some Quilombolas living in Pantanal Wetlands of Brazil

Rodrigues

Gianfratti

Tabach

et al. 2008

Phytotherapy Research

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During an ethnopharmacological survey carried out among some Quilombolas living in Brazil, 48 plants with possible central nervous system (CNS) action were cited. A mixture of nine plants, known as 'Tira-capeta' (Removing the Devil) cigarette, has been utilized for years as a tonic for the brain. The effects observed after consuming this cigarette are: dizziness, lightness sensation, humor changes, yawns, heavy eyes, hunger, sleep and relaxation. This study aimed to verify the effects of a hydroalcohol extract of 'Tira-capeta' cigarette (ETC), as well as to evaluate the phytochemical profile. The phytochemical screening carried out through characterization reactions, thin layer chromatography and high efficiency liquid chromatography indicated the presence of tannins, phenolic acids, flavonoids, saponins and alkaloids; tannins and phenolic acids being the principal constituents. The pharmacological tests showed that ETC induced a biphasic effect, with intense initial stimulation of the CNS, followed by a general depressor state; decreased the latency for sleeping and increased the total sleeping time (50, 100 and 500 mg/kg), without causing prejudice in motor coordination (doses up to 200 mg/kg); induced catalepsy in mice, verified 10 and 50 min after drug administration (500 mg/kg). Also, no anxiolytic or anxiogenic effects were verified in rats submitted to the elevated plus-maze.

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Identification of Six Phenylpropanoids from Garlic Skin as Major Antioxidants

Cited by 80 publications

References 12 publications

The atherosclerotic heart disease and protecting properties of garlic: contemporary data

The atherosclerotic heart disease and protecting properties of garlic: contemporary data

Phenylpropanoids and Fatty Acids Levels in Roots and Leaves of Datura Stramonium and Datura Innoxia

Preliminary investigation of the central nervous system effects of ‘Tira‐capeta’ (Removing the Devil), a cigarette used by some Quilombolas living in Pantanal Wetlands of Brazil

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