Landslides are one of the most common natural disasters in Indonesia. The Tana Toraja area has not been spared landslides, especially in the Makale Selatan district. Makale Selatan is one of the supply areas for agricultural products in South Sulawesi. Therefore it is necessary to map landslide-prone areas to support landslide disaster mitigation. This study aims to map landslide-prone regions and determine the factors most influencing landslide events in Makale Selatan. This study uses an Analytical Hierarchy Process (AHP) method with a weighting factor. The parameters, namely; slope, rainfall, land use, soil texture, soil type, and rock formations. The results showed that the incidence of landslides in Makale Selatan was strongly influenced by the slope, with the highest weighting factor with a weight of 0.410 (Score of 41%). Rainfall and land use with the same weight of 0.170 (Score of 17%), then the parameters of soil type and soil texture also with the exact weight is 0.096 (score of 9.6%), and the rock formation parameters with a weight of 0.058 (score 5.8%). The level of landslide-prone areas in the study area namely; 12.46% for the not prone area, 51.72% for slightly prone, prone areas 25.72%, and very prone was 10.11% for the total study area. The not-prone village is Tiromanda, and the most prone village is Lembang Randan Batu. The slope parameter is the parameter that most influences landslides in Makale Selatan. Land use for agriculture must be mechanically conserved to reduce the slope angle and prevent landslides.