Identification of Soluble Epoxide Hydrolase Inhibitors from the Seeds ofPassiflora edulisCultivated in Vietnam

Selective Extraction of Piceatannol from Passiflora edulis by-Products: Application of HSPs Strategy and Inhibition of Neurodegenerative Enzymes

“…Resveratrol and its analogs are usually found in significant amounts in grapes [52]. Two studies using P. edulis reported trans-resveratrol in ethanolic seed extracts [53] and resveratrol, with the use of acetone extraction assisted by the ultrasound of P. edulis by-products [34]. Other stilbenes identified in this work were classified as piceatannol derivatives, and were recently found in P. edulis by Pan et al [43], named passiflorinol C/D-type isomers, cyperusphenol B, passiflorinol A/B-type isomers, cyperusphenol D, and cassigarol D. The same authors elucidate the potential of such compounds as hypoglycemic agents due to the promising results in α-glucosidase inhibitory activities, where passiflorinol B exhibited the best results, achieving an IC 50 = 1.7 µM.…”

“…Since then, few papers have identified this isomer in other plant species or evidenced their biological potential. However, some of their isomers, which include cassigarol A and cassigarol E, were found to be potential inhibitors of gastric enzymes [56] and soluble epoxy hydrolases [53]. Finally, Rasouli et al [57] investigated how the natural polyphenols presented in plants could help with diabetes treatment.…”

Anti‐Alzheimer's Activity of Polyphenolic Stilbene‐Rich Acetone Fraction of the Oil‐Removed Seeds of Passiflora edulis: in Vivo and in Silico Studies

“…There have been many articles published on purple passion fruit (P. edulis Sims) to date. [6][7][8][9] This purple species was imported and is increasingly cultivated in Vietnam, from the north to the south, on over ten thousand hectares in the Son La, Nghe An, and Tay Nguyen areas. [9] The fruits of this plant are typically used to make juice.…”

“…[6][7][8][9] This purple species was imported and is increasingly cultivated in Vietnam, from the north to the south, on over ten thousand hectares in the Son La, Nghe An, and Tay Nguyen areas. [9] The fruits of this plant are typically used to make juice. The young leaves can be used as leafy vegetables.…”

Biomolecular interactions and inhibition kinetics of human soluble epoxide hydrolase by tetrapeptide YMSV

“…Cv. Habanero (Kim et al, 2019), phenolic compounds from Vietnam's Passiflora edulis seeds (Cuong et al, 2019), anthraquinone and stilbene derivatives from Rheum undulatum (Jo et al, 2016), as well as triterpenes and phenylpropanoid derivatives from Lycopus lucidus roots (Han et al, 2021). However, these natural sEH inhibitors have poor pharmacokinetics properties, including low water solubility, absorption in the gastrointestinal tract, and bioaccessibility (Lee et al, 2020).…”