Identification of Some Analogs of the Hallucinogen Phencyclidine

Abstract

The drugs 1-[1-(2-thienyl)cyclohexyl]piperidine, 1-[1-(2-thienyl) cyclohexyl] morpholine, 1-[1-(2-thienyl)cyclohexyl] pyrrolidine, 1-(1-phenylcyclohexyl) morpholine, and 1-(1-phenylcyclohexyl) pyrrolidine are identified by spectroscopic techniques. The ultraviolet and proton magnetic resonance spectra of analogs are similar, but mass and infrared spectra are distinctly different, and reference spectra are provided. Gas-liquid and thin layer chromatographic systems for the analysis are discussed.

Syntheses, analytical and pharmacological characterizations of the ‘legal high’ 4‐[1‐(3‐methoxyphenyl)cyclohexyl]morpholine (3‐MeO‐PCMo) and analogues

“…Under EI conditions, both the molecular ion and a [M − H • ] + species were visible in appreciable relative abundance and implementation of CI facilitated detection of the corresponding protonated molecules. The EI mass spectrum obtained in the present study for PCMo was comparable with a spectrum published 40 years ago although differences were observed in the relative abundance of various fragments, possibly due to implementation of different mass analyzers. CI mass spectra of PCMo, using both methane and isobutane as the reagent gas, appeared 3–4 years later, which revealed the formation of fragment ions also detected in the present study, such as m / z 88, m / z 159 and m / z 202.…”

“…HCl salt was obtained as the hemihydrate ( 1 H NMR) white powder with a melting point of 197.3–198.5°C (lit. 187–188°C ; 188–190°C ; 187–188°C ; 181–182°C ; 199–201°C (hemihydrate) ; 182°C). An alternative route for the synthesis of PCMo was also employed and is provided in the supporting information.…”