Identification of sources of brain neuronal activity with high spatiotemporal resolution through combination of neuromagnetic source localization (NMSL) and magnetic resonance imaging (MRI)

Pantev, Christo; Hoke, M.; Lehnertz, Klaus; Lütkenhöner, Bernd; Fahrendorf, G.; Stöber, U.

doi:10.1016/0013-4694(90)90171-f

Cited by 113 publications

(45 citation statements)

References 14 publications

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“…The results obtained with regard to the tonotopic organization of the N1m generator are basically consistent with numerous earlier studies [Pantev et al, 1988[Pantev et al, , 1989[Pantev et al, , 1990[Pantev et al, , 1995Yamamoto et al, 1988;Cansino et al, 1994]. However, the present study adds several details which disprove the naive assumption of a single tonotopically organized generator.…”

Section: Generator Structuresupporting

confidence: 77%

“…1 Projections of the estimated dipole locations into magnetic resonance (MR) images showed that peak N1m originates from generators located in the depth of the sylvian fissure [Yamamoto et al, 1988;Pantev et al, 1990;Papanicolaou et al, 1990;Nakasato et al, 1995]. Evidence was given that the crucial stimulus parameter is the virtual pitch and not the frequency spectrum [Pantev et al, 1989].…”

Section: Introductionmentioning

confidence: 99%

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High-Precision Neuromagnetic Study of the Functional Organization of the Human Auditory Cortex

1998

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Previous studies have proven that a dipole source analysis of the auditory evoked field is capable of providing evidence of the tonotopic organization of the human auditory cortex. To explore the nature of the estimated dipoles in greater detail, a single subject was extensively studied, and the estimated sources were registered in a three-dimensional reconstruction of the cortical surface derived from magnetic resonance images. The stimuli were 500-ms tone bursts with frequencies of 250, 500, 1,000, and 2,000 Hz (mean intensity of 60 dB SL). The total number of stimuli presented per condition was about 3,600 (36 independent experiments spread over 4 days). Using special postprocessing techniques, the relative localization accuracy could be enhanced to such an extent that differences in the dipole locations of 1 mm could be clearly distinguished. The results suggest that peak N1m (latency around 100 ms) arises from the planum temporale, whereas peak P2m (latency around 170 ms) appears to correspond to a center of activity in (or close to) Heschl’s gyrus. The tonotopic organization found for the generator of N1m was consistent with earlier studies (‘the higher the frequency the deeper the source’). However, additional findings (time dependence of the estimated sources; slightly different tonotopy obtained for field change; dependence of the estimated sources on the estimation technique) indicate that multiple areas are involved in the generation of N1m. Evidence of a frequency-dependent source location was found also for P2m.

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Section: Generator Structuresupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

High-Precision Neuromagnetic Study of the Functional Organization of the Human Auditory Cortex

1998

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“…This view receives support from the localization results for the SP reported by Scherg et al (1989) and Scherg and Picton (1991), and the localization of the SF reported by Hari (1980) and Hari et al (1980Hari et al ( , 1987. These authors found the sources of the SP and the SF to be located in the supratemporal cortex near the sources of the major component of the slow AEF (M100), having a latency of about 100 msec after the stimulus onset, which has been repeatedly shown to indicate the location of the auditory cortex and association areas (Yamamoto et al 1988;Pantev et al 1990;Papanicolaou et al 1990;Pantev 1992). On the other hand, the magnetic counterpart of the CNV, the contingent magnetic variation (CMV), cannot be accounted for by a single equivalent dipole (Elbert et al 1993).…”

Section: * Corresponding Authormentioning

confidence: 98%

The auditory evoked sustained field: origin and frequency dependence

Pantev

Eulitz

Elbert

et al. 1994

Electroencephalography and Clinical Neurophysiology

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SummaryA sound lasting for several seconds is known to elicit a basline shift in electrical and magnetic records. We have studied the dependence of the magnetic field distribution of this "per-stimulatory" sustained field (SF) on tone frequency. Tone bursts of 2 sec duration and 60 dB nHL intensity were presented to 11 subjects at varying interstimulus intervals between 5 and 7 sec. The carrier frequencies of 250, 1000 and 4000 Hz varied randomly from trial to trial. The field distributions obtained are consistent with the view that the auditory evoked sustained field activity originates in the supratemporal cortex. Differences in the locations of equivalent current dipoles of the SF from those of the MlOO wave of the slow auditory evoked field are consistent across subjects. The SF source locations corresponding to stimulus frequencies over an extended frequency range are arranged in a tonotopic manner and support the idea that the sources of the MlOO and the SF are current dipole sheets located on the superior surface of the primary auditory cortex.

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“…A natural step in this direction would be the integration of anatomical information from magnetic resonance images (MRI). Previously, MRI data were only used to establish the plausibility of dipole locations within an anatomical context (e.g., Kuriki et al 1988;Reite et al 1988;Yamamoto et al 1988;Pantev et al 1990). The strategy for the future, however, must be to extract anatomical information from the MRI prior to the source analysis and to tailor both the source and the volume conductor model accordingly.…”

Section: Introductionmentioning

confidence: 99%

Neuromagnetic source analysis using magnetic resonance images for the construction of source and volume conductor model

Lütkenhöner¹,

Menninghaus²,

Steinsträter³

et al. 1995

Brain Topogr

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Summary: Sources of the somatosensory evoked fields (SEF) for one subject were estimated using constraints from the magnetic resonance images (MRI) of the same subject. A realistic volume conductor model was shaped corresponding to the inside of the skull. Sources were restricted to a dipole patch riding on the surface of the cortex, reconstructed from the individual MRI. Such a patch can be considered as a uniformly activated cortical area giving rise to distributed currents which flow perpendicular to the cortical surface. Source locations obtained for the SEF in response to separate stimulations of lower lip, first and fifth digit, and collarbone followed the course of the contralateral central sulcus. The order of the estimated source locations was in agreement with the somatosensory homunculus of Penfield and Rasmussen. Similar results were obtained with the simple model of a current dipole in a homogeneous sphere. In contrast, combining a current dipole model with a realistic volume conductor model was rather problematic as it overesthnates the radial dipole component by an order of magnitude.

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Identification of sources of brain neuronal activity with high spatiotemporal resolution through combination of neuromagnetic source localization (NMSL) and magnetic resonance imaging (MRI)

Cited by 113 publications

References 14 publications

High-Precision Neuromagnetic Study of the Functional Organization of the Human Auditory Cortex

High-Precision Neuromagnetic Study of the Functional Organization of the Human Auditory Cortex

The auditory evoked sustained field: origin and frequency dependence

Neuromagnetic source analysis using magnetic resonance images for the construction of source and volume conductor model

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