Identification of synaptic pattern of kainate glutamate receptor subtypes on direction-selective retinal ganglion cells

Kwon, Oh-Ju; Kim, Moon-Sook; Kim, Tae-Jin; Jeon, Chang‐Jin

doi:10.1016/j.neures.2007.03.009

Cited by 11 publications

(10 citation statements)

References 51 publications

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“…29,30,42 Thus, these previous and present results strongly suggest that glutamate receptor subtypes do not mediate asymmetric inputs on DS RGCs. Physiological and pharmacological data also support our present results showing the symmetrical distribution of NMDARs upon both the ON and OFF dendritic arbors of rabbit DS RGCs.…”

Section: Discussionsupporting

confidence: 73%

“…Detailed procedures for image analysis and our criterion for counting a punctum as a synapse have been explained in our previous reports. [28][29][30] For each NMDAR image, we calculated NMDAR immunopuncta on dendrites for each of the eight cardinal directions, that is, along the possible preferred-null directions. Immunopuncta within 45 of a given cardinal direction were included in the histogram ( Figure 6A).…”

Section: Discussionmentioning

confidence: 99%

“…We previously reported the identification of the distributions of excitatory and inhibitory inputs on DS RGCs, 28 as well as the distributions of the AMPA and KA glutamate receptor subtypes on DS RGCs. 29,30 The purpose of our present investigation was to characterize NMDA glutamate receptor subtypes upon the dendritic arbors of DS RGCs in the rabbit retina. To this end, immunocytochemistry of vibratome sections and whole mounts was carried out in the rabbit retinas.…”

Section: Introductionmentioning

confidence: 99%

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Identification of Synaptic Patterns of NMDA Receptor Subtypes Upon Direction-Selective Rabbit Retinal Ganglion Cells

Kwon

Lee

Kim

et al. 2015

Current Eye Research

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Identification of Synaptic Patterns of NMDA Receptor Subtypes Upon Direction-Selective Rabbit Retinal Ganglion Cells

Kwon

Lee

Kim

et al. 2015

Current Eye Research

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“…Although expression of the KA-1 gene has been reported in the retina (Duvoisin et al, 1995; Jakobs et al, 2007; Kwon et al, 2007; Hanna and Calkins, 2007; but see Brandstätter et al, 1994), such a unique expression pattern has not been reported. Therefore, it would not be surprising that the expression of Cre recombinase in these ganglion cells were due to a position effect, despite the fact that this mouse line was generated using a BAC clone.…”

Section: Discussionmentioning

confidence: 99%

Characterization of transgenic mouse lines expressing Cre recombinase in the retina

Ivanova¹,

Hwang²,

Pan³

2010

Neuroscience

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The mammalian retina consists of five major classes of neuronal cells, as well as glial cells, and it contains more than 50 cell types. The ability to manipulate gene expression in specific cell type(s) in the retina is important for understanding the molecular mechanisms of retinal function and diseases. The Cre/loxP recombination system has been shown to be a powerful tool, allowing gene deletion, over-expression, and ectopic expression in vivo in a cell- and tissue-specific fashion. The key to this tool is the availability of Cre mouse lines with cell- or tissue-type specific expression of Cre recombinase. To date, a large number of Cre-transgenic mouse lines have been generated to target Cre recombinase expression to specific neuronal and glial cell populations in the CNS; however, information about the expression patterns of Cre recombinase lines in the retina is largely lacking. In this study, we examined and characterized the expression patterns of Cre recombinase in the retinas of 15 Cre-transgenic mouse lines. Significant Cre-induced recombination or expression of Cre recombinase was observed in the majority of these lines. In particular, we found several Cre lines in which the Cre-induced recombination was found to target exclusively or predominantly a single type or class of retinal cells, including bistratified retinal ganglion cells, starburst amacrine cells, rod bipolar cells, and Müller glial cells. In other lines, the Cre-induced recombination was found in several retinal cell types. These Cre lines provide a valuable resource for retinal research.

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“…To elucidate whether inhibition occurs postsynaptically, various receptors or receptor subtypes need to be mapped onto morphologically and physiologically identified DSGCs, using a combination of electrophysiological recording, intracellular injection and receptor immunohistochemistry. Jeon and colleagues [54,55,65] accomplished such experiments by using a triple-labeling technique. They provided conclusive micropharmacological evidence of random distribution of both nicotinic cholinergic and glutamatergic receptors on dendrites of DSGCs.…”

Section: The Road To the Presynaptic Model Underlying Direction Selecmentioning

confidence: 99%

Cellular Inhibitory Behavior Underlying the Formation of Retinal Direction Selectivity in the Starburst Network

Poznański¹

2010

J. Integr. Neurosci.

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Optical imaging of dendritic calcium signals provided evidence of starburst amacrine cells exhibiting calcium bias to somatofugal motion. In contrast, it has been impractical to use a dual-patch clamp technique to record membrane potentials from both proximal dendrites and distal varicosities of starburst amacrine cells in order to unequivocally prove that they are directionally sensitive to voltage, as was first suggested almost two decades ago. This paper aims to extend the passive cable model to an active cable model of a starburst amacrine cell that is intrinsically dependent on the electrical properties of starburst amacrine cells, whose various macroscopic currents are described quantitatively. The coupling between voltage and calcium just below the membrane results in a voltage-calcium system of coupled nonlinear Volterra integral equations whose solutions must be integrated into a prescribed model for example, for a synaptic couplet of starburst amacrine cells. Networks of starburst amacrine cells play a fundamental role in the retinal circuitry underlying directional selectivity. It is suggested that the dendritic plexus of starburst amacrine cells provides the substrate for the property of directional selectivity, while directional selectivity is a property of the exclusive layerings and confinement of their interconnections within the sublaminae of the inner plexiform layer involving cone bipolar cells and directionally selective ganglion cells.

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Identification of synaptic pattern of kainate glutamate receptor subtypes on direction-selective retinal ganglion cells

Cited by 11 publications

References 51 publications

Identification of Synaptic Patterns of NMDA Receptor Subtypes Upon Direction-Selective Rabbit Retinal Ganglion Cells

Identification of Synaptic Patterns of NMDA Receptor Subtypes Upon Direction-Selective Rabbit Retinal Ganglion Cells

Characterization of transgenic mouse lines expressing Cre recombinase in the retina

Cellular Inhibitory Behavior Underlying the Formation of Retinal Direction Selectivity in the Starburst Network

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