Identification of the Age Related Skin Changes Using High-Frequency Ultrasound

Kozárová, Andrea; Kozar, Marek; Minarikova, E; Pappova, T.

doi:10.1515/acm-2017-0002

Cited by 12 publications

(19 citation statements)

References 14 publications

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“…In a study, 24 a significant correlation was reported between the number of pixels with a weak echo in the lower epidermis and the age of individuals. Kozarova et al 25 investigated the effect of photoaging in the skin thickness and specific structural changes in the subepidermal low echogenic band (SLEB). High‐frequency ultrasound has also been applied to evaluate the efficacy of laser in the treatment of cellulite and the changes in these images have been objectively examined 26 .…”

Section: Discussionmentioning

confidence: 99%

Effect of fullerene nanoemulsion on the repair of wrinkles induced by UVB radiation: A c57bl6 mice model

Estaji

Mokhtari‐Dizaji

Movahedin

et al. 2020

Skin Research and Technology

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Introduction The effect of fullerene nanoemulsion on skin wrinkle repair in an animal model was evaluated using ultrasonic images processing. Methods Wrinkles were created in C57BL6 mice during 35 days of UVB radiation. Then, to investigate the therapeutic effect of fullerene nanoemulsions, mice were divided into three groups of control, UVB radiation, and treatment with fullerene nanoemulsion. Stable fullerene nanoemulsions were prepared using shear equalization. The therapeutic effect of fullerene nanoemulsion was investigated by extracting the skin thickness and mechanical parameters. Histology studies were performed to confirm the reliability of the treatment. Results A significant decrease was observed in the thickness of the epidermis and dermis layers (43% and 36%), Young modulus (27%), and the shear modulus (20%) of the skin on day 28 of the fullerene nanoemulsion treatment. Skin stiffness obtained by tensiometry on day 28 of the treatment showed a 48% reduction in the treatment group compared with the control group. Histological results confirmed the effect of fullerene nanoemulsions on wrinkle repair. Conclusion The healing effect of fullerene nanoemulsion in wrinkle repair was confirmed. To study the skin repair, parameters including Young modulus, the shear modulus, and skin layer thickness can be calculated using ultrasonic images processing.

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Section: Discussionmentioning

confidence: 99%

Effect of fullerene nanoemulsion on the repair of wrinkles induced by UVB radiation: A c57bl6 mice model

Estaji

Mokhtari‐Dizaji

Movahedin

et al. 2020

Skin Research and Technology

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show abstract

“…The structural properties of the biological tissue models are listed in Table 1 . The thicknesses of the dermis and the subcutaneous tissue were determined using random numbers of uniform probability with a range of 1 to 2 mm 27 and 1 to 6 mm, 28 respectively. The structural properties of the bone tissue were based on measurements of the ultradistal radius of women by Boutroy et al.…”

Section: Methodsmentioning

confidence: 99%

Optical bone densitometry robust to variation of soft tissue using machine learning techniques: validation by Monte Carlo simulation

2022

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. Significance: To achieve early detection of osteoporosis, a simple bone densitometry method using optics was proposed. However, individual differences in soft tissue structure and optical properties can cause errors in quantitative bone densitometry. Therefore, developing optical bone densitometry that is robust to soft tissue variations is important for the early detection of osteoporosis. Aim: The purpose of this study was to develop an optical bone densitometer that is insensitive to soft tissue, using Monte Carlo simulation and machine learning techniques, and to verify its feasibility. Approach: We propose a method to measure spatially resolved diffuse light from three directions of the biological tissue model and used machine learning techniques to predict bone density from these data. The three directions are backward, forward, and lateral to the direction of ballistic light irradiation. The method was validated using Monte Carlo simulations using synthetic biological tissue models with 1211 different random structural and optical properties. Results: The results were computed after a 10-fold cross-validation. From the simulated optical data, the machine learning model predicted bone density with a coefficient of determination of 0.760. Conclusions: The optical bone densitometry method proposed in this study was found to be robust against individual differences in soft tissue.

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“…[12][13][14] Previous studies have indicated that ultrasound skin thickness and stiffness in Rodnan sites of healthy people are affected by gender and age. [15][16][17] Some influence of body mass index (BMI) 16 and hormonal status 18 have also been suggested. Normal reference curves for skin ultrasound parameters, considering relevant influential factors, seem of pivotal importance to fully exploit the potential of these new techniques as reliable tools for diagnostic and follow-up purposes.…”

Section: What This Study Addsmentioning

confidence: 99%

Normal percentile reference curves for skin ultrasound thickness and stiffness at Rodnan sites

et al. 2022

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ObjectivesOur primary objective was to establish preliminary normal reference curves for ultrasound–dermal thickness and skin stiffness in the 17 Rodnan skin sites, considering the effect of gender and age on these measures. As an exploratory objective, we investigated the effect of body mass index and the menopause on skin ultrasound measures.MethodsA cross-sectional study was conducted involving 140 healthy volunteers, aged 20–79 years. Recruitment was stratified by gender and age (10-year categories). Ultrasound–dermal thickness and skin stiffness were assessed by high-frequency ultrasound and shear-wave elastography, respectively, at the 17 Rodnan skin sites. Outcomes were evaluated through a mixed linear model, univariate and multivariate regressions. Normal reference curves were derived for both ultrasound measures in each skin site. An online calculator of the percentiles of skin ultrasound measures was developed.ResultsUltrasound–dermal thickness and stiffness measures were higher in men than women in all Rodnan skin sites (except in chest for ultrasound–dermal thickness). Age had also a significant impact in both ultrasound measures, but only in some skin sites. Gender and age percentile curves (97.5th, 95th, 75th, 50th, 25th, 5th, 2.5th) were plotted for each of the measures in each skin site.ConclusionsGender and age are strongly associated with skin ultrasound parameters, imposing the need for gender-specific and age-specific reference values. Normal reference percentile curves are provided as a basis for future cooperative work to strengthen its evidence basis, representativeness and refinement regarding potentially influential factors.

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Identification of the Age Related Skin Changes Using High-Frequency Ultrasound

Cited by 12 publications

References 14 publications

Effect of fullerene nanoemulsion on the repair of wrinkles induced by UVB radiation: A c57bl6 mice model

Effect of fullerene nanoemulsion on the repair of wrinkles induced by UVB radiation: A c57bl6 mice model

Optical bone densitometry robust to variation of soft tissue using machine learning techniques: validation by Monte Carlo simulation

Normal percentile reference curves for skin ultrasound thickness and stiffness at Rodnan sites

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