Identification of the Functional Interleukin-22 (IL-22) Receptor Complex

Kotenko, Sergei V.; Izotova, Lara S.; Mirochnitchenko, Olga; Esterova, Elena; Dickensheets, Harold; Donnelly, Raymond P.; Pestka, Sidney

doi:10.1074/jbc.m007837200

Cited by 357 publications

(100 citation statements)

References 37 publications

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“…In addition to IL-10, this protein family in humans presently includes IL-19, IL-TIF, AK-155 and IL-20. Although the extent of amino acid homology between members is not extensive (IL-10 and mda-7 share 520% sequence identity), several similarly related molecules have been discovered and from the collectively available information there is now convincing evidence to classify mda-7 as a member of the family (Gallagher et al, 2000;Xie et al, 2000;Zhang et al, 2000;Kotenko et al, 2001). Two features of mda-7 in addition to the presence of an IL-10 family signature and predicted four-helix bundle protein conformation reinforce this idea.…”

Section: Discussionsupporting

confidence: 50%

“…Among the reported protein domains present in the conceptually translated peptide sequence was an Interleukin-10 (IL-10) signature. Recent information (Chaiken and Williams, 1996;Kotenko et al, 2001; and unpublished data) strongly suggest that mda-7 belongs to the fourhelix bundle family cytokine molecules (Chaiken and Williams, 1996;Kotenko et al, 2001) most related to the IL-10 sub-family Xie et al, 2000;Kotenko et al, 2001). In addition to IL-10, this protein family in humans presently includes IL-19, IL-TIF, AK-155 and IL-20.…”

Section: Discussionmentioning

confidence: 99%

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Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties

et al. 2001

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Abnormalities in cellular di erentiation are frequent occurrences in human cancers. Treatment of human melanoma cells with recombinant ®broblast interferon (IFN-b) and the protein kinase C activator mezerein (MEZ) results in an irreversible loss in growth potential, suppression of tumorigenic properties and induction of terminal cell di erentiation. Subtraction hybridization identi®ed melanoma di erentiation associated gene-7 (mda-7), as a gene induced during these physiological changes in human melanoma cells. Ectopic expression of mda-7 by means of a replication defective adenovirus results in growth suppression and induction of apoptosis in a broad spectrum of additional cancers, including melanoma, glioblastoma multiforme, osteosarcoma and carcinomas of the breast, cervix, colon, lung, nasopharynx and prostate. In contrast, no apparent harmful e ects occur when mda-7 is expressed in normal epithelial or ®broblast cells. Human clones of mda-7 were isolated and its organization resolved in terms of intron/exon structure and chromosomal localization. Humda-7 encompasses seven exons and six introns and encodes a protein with a predicted size of 23.8 kDa, consisting of 206 amino acids. Hu-mda-7 mRNA is stably expressed in the thymus, spleen and peripheral blood leukocytes. De novo mda-7 mRNA expression is also detected in human melanocytes and expression is inducible in cells of melanocyte/melanoma lineage and in certain normal and cancer cell types following treatment with a combination of IFN-b plus MEZ. Mda-7 expression is also induced during megakaryocyte di erentiation induced in human hematopoietic cells by treatment with TPA (12-O-tetradecanoyl phorbol-13-acetate). In contrast, de novo expression of mda-7 is not detected nor is it inducible by IFN-b+MEZ in a spectrum of additional normal and cancer cells. No correlation was observed between induction of mda-7 mRNA expression and growth suppression following treatment with IFN-b+MEZ and induction of endogenous mda-7 mRNA by combination treatment did not result in signi®cant intracellular MDA-7 protein. Radiation hybrid mapping assigned the mda-7 gene to human chromosome 1q, at 1q 32.2 to 1q41, an area containing a cluster of genes associated with the IL-10 family of cytokines. Mda-7 represents a di erentiation, growth and apoptosis associated gene with potential utility for the gene-based therapy of diverse human cancers. Oncogene (2001) 20, 7051 ± 7063.

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Section: Discussionsupporting

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties

et al. 2001

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“…Current data suggest that mda-7 is a member of the four-helix bundle family of cytokine molecules (Chaiken and Williams, 1996;Kotenko et al, 2001;Huang et al, 2001) with greatest homology to the IL-10 subfamily, which now includes IL-19, IL-TIF, AK-155 and IL-20 (Gallagher et al, 2000;Zhang et al, 2000;Xie et al, 2000;. Although the extent of amino acid homology between the various members of the IL-10 family is not extensive, IL-10 and mda-7 share 520% sequence identity, the presence of an IL-10 signature sequence, a 49 amino acid N-terminal signal peptide and location in the human genome on chromosome Figure 4 Determination of intracellular and secreted MDA-7 protein in human normal immortal melanocytes and in a metastatic melanoma cell line after infection with Ad.mda-7.…”

Section: Discussionmentioning

confidence: 99%

The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells

et al. 2002

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Human melanoma cells growth arrest irreversibly, lose tumorigenic potential and terminally di erentiate after treatment with a combination of ®broblast interferon (IFN-b) and the protein kinase C activator mezerein (MEZ). Applying subtraction hybridization to this model di erentiation system permitted cloning of melanoma di erentiation associated gene-7, mda-7. Expression of mda-7 inversely correlates with melanoma development and progression, with elevated expression in normal melanocytes and nevi and increasingly reduced expression in radial growth phase, vertical growth phase and metastatic melanoma. When expressed by means of a replication incompetent adenovirus (Ad.mda-7) growth of melanoma, but not normal early passage or immortal human melanocytes, is dramatically suppressed and cells undergo programmed cell death (apoptosis). Infection of metastatic melanoma cells with Ad.mda-7 results in an increase in cells in the G 2 /M phase of the cell cycle and changes in the ratio of pro-apoptotic (BAX, BAK) to anti-apoptotic (BCL-2, BCL-XL) proteins. Ad.mda-7 infection results in a temporal increase in mda-7 mRNA and intracellular MDA-7 protein in most of the melanocyte/melanoma cell lines and secretion of MDA-7 protein is readily detected following Ad.mda-7 infection of both melanocytes and melanoma cells. The present studies document a di erential response of melanocytes versus melanoma cells to ectopic expression of mda-7 and support future applications of mda-7 for the genebased therapy of metastatic melanoma.

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“…To characterize IL-10, IL-22, and IFN-receptor complexes, we had created a series of reporter hamster cell lines that respond to these human cytokines specifically (6,29,30). Cytokines demonstrate various degrees of species specificity.…”

Section: Ifn-and Ifn-signal Through Canonical Type I Ifn Receptor Com-mentioning

confidence: 99%

Inhibition of type I and type III interferons by a secreted glycoprotein from Yaba-like disease virus

Huang

Smirnov

Lewis-Antes

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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Identification of the Functional Interleukin-22 (IL-22) Receptor Complex

Cited by 357 publications

References 37 publications

Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties

Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties

The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells

Inhibition of type I and type III interferons by a secreted glycoprotein from Yaba-like disease virus

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