The integration of building energy-saving measures during early architectural design and the energy-efficient retrofitting of existing buildings hold paramount importance in achieving carbon neutrality. This study focuses on five representative climate zones in China to assess the sensitivity of building energy consumption to ten key external envelope parameters. Leveraging two research prototypes from 18 high-rise mixed-use office buildings in the hot-summer and warm-winter climate zone (Hong Kong), the DeST platform is utilized to simulate the impact of various design parameters on the annual building load. Employing the Sobol method for quantitative analysis, the study examines the contribution of each parameter to building energy consumption. Findings reveal distinct sensitivities of building envelope parameters concerning heating load, cooling load, and total load indicators, contingent upon diverse climate regions and building types. Under the total load indicator, the heat transfer coefficients of glass and roof, along with the window-to-wall ratio on the west and south facades, emerge as the most sensitive design parameters, while the solar radiation absorptance of walls and roofs show lower sensitivity. This research offers valuable insights for energy-efficient design and building renovations, paving the way for a more sustainable and environmentally conscious future.