Identification of the Major Degradation Products of Vinorelbine by Frit-FAB LC/MS and NMR

Yamaguchi, Kazuo; Yasuzawa, Tohru; Kobayashi, Satoshi

doi:10.2116/analsci.14.1169

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…Since several bisindoles are used as active pharmaceutical ingredients, some attempts were made to characterize their metabolites [32][33][34]41], degradation products, and process-related impurities [51,[91][92][93] using NMR spectroscopy in some cases.…”

Section: Nmr Spectroscopic Studies Of Bisindole Metabolites Process-mentioning

confidence: 99%

“…Although purity is a crucial quality-control issue for any drug substance, a surprisingly small number of publications can be found in the literature dealing with the structural identification of impurities and degradants of bisindole drugs [47,51,[91][92][93].…”

Section: Nmr Spectroscopic Studies Of Bisindole Metabolites Process-mentioning

confidence: 99%

“…A detailed 1D and 2D NMR study together with MS investigations enabled the unambiguous identification of vinorelbine bitartarate degradants [92] formed under various stress conditions. In this case ca.…”

Section: Nmr Spectroscopic Studies Of Bisindole Metabolites Process-mentioning

confidence: 99%

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Structure elucidation of indole–indoline type alkaloids: A retrospective account from the point of view of current NMR and MS technology

Béni¹,

Háda²,

Dubrovay³

et al. 2012

Journal of Pharmaceutical and Biomedical Analysis

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Section: Nmr Spectroscopic Studies Of Bisindole Metabolites Process-mentioning

confidence: 99%

Section: Nmr Spectroscopic Studies Of Bisindole Metabolites Process-mentioning

confidence: 99%

See 1 more Smart Citation

Structure elucidation of indole–indoline type alkaloids: A retrospective account from the point of view of current NMR and MS technology

Béni¹,

Háda²,

Dubrovay³

et al. 2012

Journal of Pharmaceutical and Biomedical Analysis

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Rapid identification of vinca alkaloids by direct-injection electrospray ionisation tandem mass spectrometry and confirmation by high-performance liquid chromatography-mass spectrometry

et al. 2005

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A simple and rapid method for the identification of Vinca alkaloids from a crude extract of Catharanthus roseus G. Don (Apocynaceae) by direct-injection electrospray ionisation (ESI) and tandem mass spectrometry (MS/MS) has been developed. The alkaloids vindoline, vindolidine, vincristine and vinblastine were evaluated in a commercial extract of C. roseus using this method. Catharanthine and its isomers 19S-vindolinine and vindolinine were detected in the commercial product by direct injection ESI/MS/MS and confirmed by preparation and by HPLC-ESI/MS. For the characterisation of different fragment fingerprints, ESI/MS/MS is a sensitive, rapid and convenient technique by which to identify some constituents in complex and mixed plant extracts.

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Identification of the Major Degradation Products of Vinorelbine by Frit-FAB LC/MS and NMR

Cited by 2 publications

References 7 publications

Structure elucidation of indole–indoline type alkaloids: A retrospective account from the point of view of current NMR and MS technology

Structure elucidation of indole–indoline type alkaloids: A retrospective account from the point of view of current NMR and MS technology

Rapid identification of vinca alkaloids by direct-injection electrospray ionisation tandem mass spectrometry and confirmation by high-performance liquid chromatography-mass spectrometry

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