Identification of the most common cutaneous neoplasms in dogs and evaluation of breed and age distributions for selected neoplasms

Villamil, J. Armando; Henry, Carolyn J.; Bryan, Jeffrey N.; Ellersieck, Mark R.; Schultz, Loren G.; Tyler, Jeff W.; Hahn, Allen W.

doi:10.2460/javma.239.7.960

Cited by 98 publications

(139 citation statements)

References 6 publications

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“…Depending on the degree differentiation of MCTs determines not only the diverse morphology and metastatic potential of tumours but also the response to therapy and prognosis (Dobson et al 2002, Murphy et al 2004, Dobson et al 2007, Brznden et al 2010. Furthermore, as reported in the literature, the development and behaviour of MCTs is closely associated with dogs' breed, age, and sex as well as the location of the neoplasm (Dobson et al 2002, White et al 2011, Villamil et al 2011, Warland and Dobson 2013, Zinc et al 2014. Boxers are at the greatest risk of the disease, but Shar-Peis, Rhodesian Ridgebacks, Pugs, Weimaraners, Labrador Retrievers, Beagles, and Golden Retrievers are frequently mentioned in this context as well (Dobson 2013).…”

Section: Introductionmentioning

confidence: 94%

“…Mast cell tumours (MCTs) are the most frequent canine skin tumours as they account for 7-21% of all diagnosed neoplastic lesions of this organ (Welle et al 2008, Villamil et al 2011. Depending on the degree differentiation of MCTs determines not only the diverse morphology and metastatic potential of tumours but also the response to therapy and prognosis (Dobson et al 2002, Murphy et al 2004, Dobson et al 2007, Brznden et al 2010.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological Study of Canine Mast Cell Tumours According to the Histological Malignancy Grade

Śmiech¹,

Ślaska²,

Łopuszyński³

et al. 2017

Polish Journal of Veterinary Sciences

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The aim of the study was to identify significant relationships between the tumour malignancy grade and dogs' age, breed, sex, size, and location of mast cell tumours (MCTs). MCTs accounted for 13.27% of all diagnosed canine skin tumours. The highest incidence was recorded among Boxers, Labrador Retrievers, American Staffordshire Terriers, and Golden Retrievers. Statistical analysis revealed significantly higher probability of occurrence of the grade I mast cell tumour in the French Bulldog in the head, neck, torso, and limb regions, the grade-II mast cell tumour in Boxer, Doberman, Dachshund, shepherds, and setters in the scrotal region, and the grade III mast cell tumour in Shar-Pei in the axilla region. In the group of the oldest dogs aged 11-16, there was higher risk of development of MCTs grade II and III. Young dogs (aged 2-3 and 4-6) were found to be more prone to development of MCTs grade I. There was no correlation between MCTs grade and dogs' sex and size. To the authors' knowledge this is the first report on statistical relationships between the degree of mast cell tumour malignancy and dogs' phenotypic traits, age and tumour location. This analysis indicate predilections for development of the particular mast cell tumour malignancy degrees in certain dog breeds, age, and anatomical location.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Epidemiological Study of Canine Mast Cell Tumours According to the Histological Malignancy Grade

Śmiech¹,

Ślaska²,

Łopuszyński³

et al. 2017

Polish Journal of Veterinary Sciences

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“…However, animals with pale skin and hair color are at increased risk of solar injury 1. The 2 most prevalent neoplastic lesions induced by ultraviolet irradiation are cutaneous squamous cell carcinoma (SCC) in dogs and cats, and cutaneous hemangiosarcoma 1, 2, 3, 4, 5, 6, 7…”

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confidence: 99%

Electroporation Enhances Bleomycin Efficacy in Cats with Periocular Carcinoma and Advanced Squamous Cell Carcinoma of the Head

Spugnini¹,

Pizzuto²,

Filipponi

et al. 2015

Veterinary Internal Medicne

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BackgroundAdvanced carcinoma of the head represents a substantial health problem in cats for local control and overall survival.ObjectivesEvaluate the capability of electrochemotherapy (ECT) to improve bleomycin efficacy in cats with periocular carcinoma and advanced carcinoma of the head.AnimalsTwenty‐one cats with periocular carcinoma (17 squamous cell carcinoma [SCC] and 4 anaplastic carcinoma) and 26 cats with advanced SCC of the head.MethodsNonrandomized prospective controlled study. Periocular carcinoma cohorts: 12 cats were treated with bleomycin (15 mg/m2 IV) coupled with ECT under anesthesia; 9 cats were treated with bleomycin alone. Advanced head SCC cohorts: 14 cats were treated with bleomycin (15 mg/m2 IV) coupled with ECT administered under sedation; 12 control cats were treated with bleomycin alone. ECT treatments (2–8) were performed every other week until complete remission (CR) or tumor progression occurred.ResultsToxicities were minimal and mostly treated symptomatically. Overall response rate in the ECT treated animals was 89% (21 Complete Response [CR] and 2 Partial Response [PR]) whereas controls had response rate of 33% (4 CR and 3 PR). Median time to progression in ECT group was 30.5 months, whereas in controls it was 3.9 months (P < .0001). Median time to progression for ECT cohorts was 24.2 months for periocular cohort and 20.6 in advanced head SCC cohort, respectively.ConclusionsElectrochemotherapy is well tolerated for advanced SCC of the head in cats; its use may be considered among loco‐regional strategies for cancer therapy in sensitive body regions such as periocular region.

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“…This finding agrees with that recorded by Mikaelian and Gross (2002) who reported sixteen dogs (2-12 years of age) with one (n = 15) or two (n = 1) cutaneous keloidal fibroma. In contrast, the most frequent age range for dogs with cutaneous neoplasms was 10-15 years (Villamil et al, 2011).…”

Section: Discussionmentioning

confidence: 86%

A Gigantic Cutaneous Fibroadenoma in a Dog

Abu‐Seida¹,

Saleh²

2015

Asian J. of Animal Sciences

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Mixed skin tumors are uncommon in dogs. This study reports the clinical findings, radiography, ultrasonography, histopathology and clinical outcome of a rare case of gigantic fibroadenoma in a 4-year-old American Pit Bull Terrier bitch. Four firm, painless at palpation, poorly circumscribed swellings of various sizes and shapes were observed at the left hock joint and hind canon. Mixed echo pattern of the neoplasm and central large blood vessels were observed under doppler ultrasonography. The neoplasm was surgically excised with complete remission and the dog was still disease-free after 6 months. The excised tumor weighted 2350 g. Histopathological findings included; diffuse bundles of fibrous connective tissue arranged in different direction with whorl formation, sebaceous glands adenoma with cyst formation and fibroadenoma in certain areas. Tendency of malignancy was common dented by pleomorphic cells, hyperchromacia and atypical mitotic figures. Several areas of inflammatory reaction and hemorrhages were also observed within the tumor. No evidence of metastasis was seen in both chest and abdomen. In conclusion, fibroadenoma should be listed as a mixed skin neoplasm in dogs and surgical excision is curative.

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Identification of the most common cutaneous neoplasms in dogs and evaluation of breed and age distributions for selected neoplasms

Cited by 98 publications

References 6 publications

Epidemiological Study of Canine Mast Cell Tumours According to the Histological Malignancy Grade

Epidemiological Study of Canine Mast Cell Tumours According to the Histological Malignancy Grade

Electroporation Enhances Bleomycin Efficacy in Cats with Periocular Carcinoma and Advanced Squamous Cell Carcinoma of the Head

A Gigantic Cutaneous Fibroadenoma in a Dog

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