Preventing multimorbidity in low-income and rural communities requires a multifaceted approach that addresses the underlying social determinants of health, improves access to healthcare, and empowers individuals to take control of their health. Evidence from various countries demonstrates the effectiveness of health education, community-based interventions, policy changes, and integrated care models in reducing the burden of multimorbidity. General internists and family physicians can play a crucial role in implementing these strategies and advocating for policies that support the health of vulnerable populations.