Identification of the novel HLA‐B*40:357 allele by polymerase chain reaction sequence‐based typing

Abstract

HLA‐B*40:357 shows a substitution C to G at position 263 when compared to HLA‐B*40:01:01.

Identification of the novel HLA‐C*12:391 allele by next‐generation sequencing

“…The HLA genes located within the human Major Histocompatibility Complex (MHC) on the short arm of chromosome 6 are thought to be the most polymorphic in the human genome 1 . HLA molecules play a central role in the immune response presenting peptides and allowing for the discrimination of self and non‐self antigens 2,3 . To date, 36,814 alleles have been identified according to the IPD‐IMGT/HLA Database Release 3.53 version 4 .…”

“…1 HLA molecules play a central role in the immune response presenting peptides and allowing for the discrimination of self and non-self antigens. 2,3 To date, 36,814 alleles have been identified according to the IPD-IMGT/HLA Database Release 3.53 version. 4 Here, we report the novel allele, HLA-C*12:391, identified in a Chinese bone marrow donor, that differs from the HLA-C*12:44 allele by a three nucleotide substitution.…”