2020
DOI: 10.3892/ol.2020.12303
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Identification of the potential roles of ring finger protein 8 in TP53‑mutant breast cancer

Abstract: Breast cancer is one of the malignant tumors with the highest mortality rate. With the development of precise treatment technology for cancer, numerous molecular targets have been identified and applied in the treatment of diseases. The present study investigated the potential role of ring finger protein 8 (RNF8) in TP53-mutant breast cancer and explored its possible mechanisms of action through a combination of bioinformatics techniques and cell biology. The results revealed that significantly different genes… Show more

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Cited by 8 publications
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“…Additionally, this study compared the tumor mutation burden and mutation status of genes between high-risk and low-risk groups. The impact of tumor mutation burden on prognosis was explored through Kaplan-Meier (KM) analysis ( Zhao et al, 2021 ).…”
Section: Methodsmentioning
confidence: 99%
“…Additionally, this study compared the tumor mutation burden and mutation status of genes between high-risk and low-risk groups. The impact of tumor mutation burden on prognosis was explored through Kaplan-Meier (KM) analysis ( Zhao et al, 2021 ).…”
Section: Methodsmentioning
confidence: 99%