Identification of the receptor for toxin IIα from scorpion Leirus quinquestriatus in isolated lobster and squid nerve membranes

The sodium channel of excitable and non-excitable cells

“…The [ 3 H]TTX binding activity co-purified with a polypeptide of about 240-280K, though other peptides were also present in variable amounts (Villegas et al 1987). It is interesting to point out that a 125 I-photoactive derivative of LqTx, used to label the a-scorpion toxin receptors of lobster nerve and rat brain, was located in a unique polypeptide of about 230K in the lobster nerve and in two of 240K and 40K in the rat brain (Delgado & Barnola, 1986). These findings suggest that the lobster nerve Na channel, like that of Electrophorus, is made up of a single large polypeptide.…”