Identification of the up-regulation of TP-alpha, collagen alpha-1(VI) chain, and S100A9 in esophageal squamous cell carcinoma by a proteomic method

Expression of tumor growth related genes in IRE1 knockdown U87 glioma cells: effect of hypoxia

“…There is data that high level of COL6A1 gene expression is observed in surgical samples from patients with glioblastomas and in esophageal squamous cell carcinoma [22,23]. Thus, COL6A1 protein possibly plays an important role in tumorigenesis [22,23]. Therefore, our results concerning strong down-regulation of COL6A1 gene expression in glioma cells upon inhibition of IRE1 completely agree with the functional role of this protein in tumor cells and with suppression of IRE1 knockdown glioma cell proliferation [7,22].…”

“…1). There is data that high level of COL6A1 gene expression is observed in surgical samples from patients with glioblastomas and in esophageal squamous cell carcinoma [22,23]. Thus, COL6A1 protein possibly plays an important role in tumorigenesis [22,23].…”

“…Among them BRCA1 (breast cancer 1, early onset) gene encodes a nuclear phosphoprotein, a regulatory subunit of protein phosphatase 1 that takes part in ubiquitination and transcriptional regulation to maintain genomic stability, and it also acts as a tumor suppressor [21]. COL6A1 (collagen type VI alpha 1) protein plays an important role in tumorigenesis [22,23]. Tumor protein D52 (TPD52) plays diffe rent roles in various types of malignancies.…”

Comparative Serum Proteomic Analysis of Serum Diagnosis Proteins of Colorectal Cancer Based on Magnetic Bead Separation and MALDI-TOF Mass Spectrometry

“…Another recent study confirmed the decreased serum levels of apolipoprotein C-1 in CRC (Engwegen et al, 2008). Additionally, protein markers associated with lymph node metastases in colorectal and prostate cancer have been profiled (Pang et al, 2010;Fan et al, 2011).…”

“…Preliminary studies have shown that this technique may provide a novel noninvasive means of diagnosing CRC, and it may have additional value as a prognostic tool (Boja et al, 2012;Cadeco et al, 2012;Garay et al, 2012;HeckmanStoddard et al, 2012). Serum proteome analysis has the potential to facilitate disease diagnosis and therapeutic monitoring, because serum is more easily accessible and widely collected sample, which contains >10,000 different proteins and peptides (Fan et al, 2011;Pan et al, 2011;. These proteins and peptides are from almost every tissue and cell, and the changes in their quantity and quality are specific not only to the tissues affected but also to the disease process itself.…”