2003
DOI: 10.1074/jbc.m300720200
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Identification of TIFA as an Adapter Protein That Links Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) to Interleukin-1 (IL-1) Receptor-associated Kinase-1 (IRAK-1) in IL-1 Receptor Signaling

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Cited by 92 publications
(117 citation statements)
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“…In fact, TRAF-interacting protein with a forkhead-associated domain (TIFA) was found to interact with TRAF6, thereby inducing TRAF6 oligomerization and enhancing TRAF6 ubiquitinating activity [50]. Endogenous TIFA constitutively associates with TRAF6, whereas it only interacts with IRAK-1 upon IL-1 stimulation [51]. In addition, overexpression of TIFA induces NF-kB and JNK activation in HEK293 cells [52].…”
Section: Il-1r and Tlr-4 Signaling To Nf-kbmentioning
confidence: 99%
“…In fact, TRAF-interacting protein with a forkhead-associated domain (TIFA) was found to interact with TRAF6, thereby inducing TRAF6 oligomerization and enhancing TRAF6 ubiquitinating activity [50]. Endogenous TIFA constitutively associates with TRAF6, whereas it only interacts with IRAK-1 upon IL-1 stimulation [51]. In addition, overexpression of TIFA induces NF-kB and JNK activation in HEK293 cells [52].…”
Section: Il-1r and Tlr-4 Signaling To Nf-kbmentioning
confidence: 99%
“…This is followed by intensive autophosphorylation of IRAK1 [5,6], its interaction with TRAF6 and subsequent dissociation of IRAK1 and TRAF6 as binding partners from the receptor complex [8][9][10]. TRAF6 then interacts with TIFA (TRAF-interacting protein with a FHA domain), which promotes oligomerization and ubiquitylation (Box 1) of the former [11]. In this process, TRAF6 interacts with the E2 ubiquitin-conjugating heterodimer UbcH13-Uev1a, resulting in covalent attachment of Lys63-linked polyubiquitin chains to TRAF6 [12].…”
Section: The Importance Of Pellino Proteins For Tlr Signallingmentioning
confidence: 99%
“…Candidates include the PKC -associated bridge between RIP and TRAF6, p62 (48); the IL-1 signal-dependent TRAF6-associated factors, TIFA (49) and Pellino (50); the TRAF6 mediators of a TAK1-like activation, Ubc13͞Uev1a (39); and the potential scaffold for TRAF3 and TRAF6, TANK (51).…”
Section: Discussionmentioning
confidence: 99%