2023
DOI: 10.1101/2023.04.28.538684
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Identification of transcription factor co-binding patterns with non-negative matrix factorization

Abstract: Transcription factor (TF) binding to DNA is critical to transcription regulation. Although the binding properties of numerous individual TFs are well-documented, a more detailed comprehension of how TFs interact cooperatively with DNA, forming either complex or co-binding to the same region, is required. Indeed, the combinatorial binding of TFs is essential to cell differentiation, development, and response to external stimuli. We present COBIND, a novel method based on non-negative matrix factorization (NMF) … Show more

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