2024
DOI: 10.1038/s41467-024-49724-w
|View full text |Cite
|
Sign up to set email alerts
|

Identification of unique cell type responses in pancreatic islets to stress

Marlie M. Maestas,
Matthew Ishahak,
Punn Augsornworawat
et al.

Abstract: Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing from human samples and studies using in vitro and in vivo models suggest that endoplasmic reticulum and inflammatory signaling play an important role in diabetes progression. To better characterize cell type-specific stress response, we perform multiplexed single-cell RNA sequencing to define the transcriptional signature of primary human islet cells exposed to endoplasmic reticulum and inflammatory stress. Through co… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
3
2

Relationship

1
4

Authors

Journals

citations
Cited by 5 publications
references
References 119 publications
0
0
0
Order By: Relevance