Identification of USP29 as a key regulator of nucleotide biosynthesis in neuroblastoma through integrative analysis of multi-omics data

Kang, Ye; Yu, Y. H.; Liu, Yijia; Pan, Yiwen; Zhang, Ru; Ren, Doudou; Cai, Zemin; Ma, Junpeng; Xiong, Xiaofan; Zhang, Qi; Zhang, Chengsheng; Tu, Rongfu

doi:10.1080/15384047.2023.2237200

Cited by 2 publications

(3 citation statements)

References 26 publications

(47 reference statements)

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“…13 Through integrative analysis of multiomics data, we recently identified USP29 as a key regulator of nucleotide biosynthesis in neuroblastoma cells, possibly by regulating MYC and E2F downstream pathways. 23 Consistent with our studies, USP29 was also reported to promote glycolysis by deubiquitinating and stabilizing HIF1α in hepatocellular carcinoma cells, thereby sustaining sorafenib resistance. 23 These findings suggest that USP29 plays a crucial role in regulating cancer cell metabolic reprogramming.…”

Section: Cancer Metabolismsupporting

confidence: 90%

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The emerging role of USP29 in cancer and other diseases

Zhang,

Cai,

Ren

et al. 2024

Cell Biochemistry & Function

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Reversible protein ubiquitination is a key process for maintaining cellular homeostasis. Deubiquitinases, which can cleave ubiquitin from substrate proteins, have been reported to be deeply involved in disease progression ranging from oncology to neurological diseases. The human genome encodes approximately 100 deubiquitinases, most of which are poorly characterized. One of the well‐characterized deubiquitases is ubiquitin‐specific protease 29 (USP29), which is often upregulated in pathological tissues and plays important roles in the progression of different diseases. Moreover, several studies have shown that deletion of Usp29 in mice does not cause visible growth and developmental defects, indicating that USP29 may be an ideal therapeutic target. In this review, we provide a comprehensive summary of the important roles and regulatory mechanisms of USP29 in cancer and other diseases, which may help us better understand its biological functions and improve future studies to construct suitable USP29‐targeted therapy systems.

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Section: Cancer Metabolismsupporting

confidence: 90%

“…23 Consistent with our studies, USP29 was also reported to promote glycolysis by deubiquitinating and stabilizing HIF1α in hepatocellular carcinoma cells, thereby sustaining sorafenib resistance. 23 These findings suggest that USP29 plays a crucial role in regulating cancer cell metabolic reprogramming.…”

Section: Cancer Metabolismsupporting

confidence: 90%

The emerging role of USP29 in cancer and other diseases

Zhang,

Cai,

Ren

et al. 2024

Cell Biochemistry & Function

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“…The study has shown that CRISPR-mediated depletion of ubiquitin-specific peptidase 29 (USP29) leads to the disruption of intermediates accountable for involvement in glycolysis and nucleotide biosynthesis in neuroblastoma cell lines ( Chandrasekaran et al, 2021 ). USP29 has also been shown to promote neuroblastoma progression by upregulating glycolysis and glutamine catabolism ( Kang et al, 2023 ). The study has also been conducted to target ferroptosis as an attractive strategy in cancer therapy ( Alborzinia et al, 2023 ).…”

Section: Applications Of Crispr/cas9 In Cancer Preclinical Studiesmentioning

confidence: 99%

Engineering CRISPR/Cas9 therapeutics for cancer precision medicine

Sharma,

Giri

2024

Front. Genet.

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The discovery of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated protein 9 (Cas9) technology has revolutionized field of cancer treatment. This review explores usage of CRISPR/Cas9 for editing and investigating genes involved in human carcinogenesis. It provides insights into the development of CRISPR as a genetic tool. Also, it explores recent developments and tools available in designing CRISPR/Cas9 systems for targeting oncogenic genes for cancer treatment. Further, we delve into an overview of cancer biology, highlighting key genetic alterations and signaling pathways whose deletion prevents malignancies. This fundamental knowledge enables a deeper understanding of how CRISPR/Cas9 can be tailored to address specific genetic aberrations and offer personalized therapeutic approaches. In this review, we showcase studies and preclinical trials that show the utility of CRISPR/Cas9 in disrupting oncogenic targets, modulating tumor microenvironment and increasing the efficiency of available anti treatments. It also provides insight into the use of CRISPR high throughput screens for cancer biomarker identifications and CRISPR based screening for drug discovery. In conclusion, this review offers an overview of exciting developments in engineering CRISPR/Cas9 therapeutics for cancer treatment and highlights the transformative potential of CRISPR for innovation and effective cancer treatments.

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Identification of USP29 as a key regulator of nucleotide biosynthesis in neuroblastoma through integrative analysis of multi-omics data

Cited by 2 publications

References 26 publications

The emerging role of USP29 in cancer and other diseases

The emerging role of USP29 in cancer and other diseases

Engineering CRISPR/Cas9 therapeutics for cancer precision medicine

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