Identification of vanilloid compounds in grains of paradise and their effects on sympathetic nerve activity

Abstract

This study suggested that GP extract and 6-gingerol were largely unrelated to the anti-obesity effect by the activation of interscapular BAT-SNA and had a different anti-obesity mechanism to capsaicin. © 2018 Society of Chemical Industry.

6‐Paradol Acts as a Potential Anti‐obesity Vanilloid from Grains of Paradise

“…The extract was dried under reduced pressure and successively partitioned into n ‐hexane, ether, ethyl acetate, and methanol. 6‐Gingerol was isolated from the n ‐hexane extract as previously described [ 15 ] and was used for animal experiments after measurement of the naturally occurring optical purity ([α] d +27 ( c = 1.2, CHCl 3 )). The major ingredients of GOP (6‐paradol, 6‐gingerol, and 6‐shogaol) were synthesized using the reported methods, [ 17,18,41 ] and the detailed procedures are provided in the Supporting Information.…”

“…Interestingly, although 6‐gingerol structurally resemble capsaicin that is known to have an anti‐obesity effect by thermogenesis through the activation of sympathetic nerve activity, 6‐gingerol showed the anti‐obesity effect in a thermogenesis‐independent manner. [ 15,16 ] It is unclear how the GOP constituents mediate anti‐obesity effect, in spite of several mechanisms for lipogenesis, lipolysis, lipid absorption and transportation, and adipocyte differentiation. Thus, we hypothesized that the active compounds in the GOP extract exhibit anti‐obesity properties via multiple mechanisms.…”

Extract from the Seeds of Aframomum melegueta Alters Acetaminophen Oral Bioavailability in Sprague Dawley Rats

“…It is also a plant widely distributed in West Africa and renowned for quite a long time, for its medicinal properties and ubiquitous use; both as spice and folkloric remedy. 1 In Africa, Aframomum species have been traditionally used to treat illnesses such as inflammation, 2 hypertension, diarrhea, stomachache, bacterial infection, 3,4, and obesity. 5,2,22 Interest in this plant in recent times has brought attention to its various potential health benefits which are attributed to both its little known class of arylalkanoids and the widely known phenolic components.…”

Optimization for Ultrasonic-Assisted Extraction of Aframomum melegueta Phenolics Using Response Surface Methodology

“…The major isolates were identifies as C1, 6paradol [8]; C2, 6-shogaol [27] and C3, 6-gingerol [28]. The structure, 1 H-NMR and 13 C-NMR spectral data of these compounds are shown in Table S1 and Figs.…”

“…Aframomum melegueta K. Schum seeds (AMS) is an African plant consumed not only as a spice but also for its valuable pharmacological activities such as antihyperlipidemic [1], antioxidant [2], antimicrobial [3], hepato-protective [4], anti-cancer [5], anti-diabetic [6] and aphrodisiac [7] effects. AMS contain a variety of bioactive phenolics, whereas 6-gingerol, 6-shogaol and 6-paradol were assigned as its major individual phenolic compounds [8]. 6-gingerol [9][10][11] and 6-shogaol [12] exhibit potent anti-inflammatory, antioxidant, anticancer, analgesic and antiemetic effects.…”