Identification of ZIP8-induced ferroptosis as a major type of cell death in monocytes under sepsis conditions

Zhang, Tong; Wang, Sheng; Hua, Dongsheng; Shi, Xuan; Deng, Huimin; Jin, Shuqing; Lv, Xin

doi:10.1016/j.redox.2023.102985

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Cited by 5 publications

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International Immunopharmacology

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STEAP3-SLC39A8-mediated microglia ferroptosis involved in neurotoxicity in rats after exposure to lead and cadmium combined

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The molecular underpinnings of female predominance in lupus

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Ferroptosis: principles and significance in health and disease

Chen,

Kang,

Tang

et al. 2024

J Hematol Oncol

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Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecular networks involving diverse molecules and organelles. Since its recognition as a non-apoptotic cell death pathway in 2012, ferroptosis has emerged as a crucial mechanism in numerous physiological and pathological contexts, leading to significant therapeutic advancements across a wide range of diseases. This review summarizes the fundamental molecular mechanisms and regulatory pathways underlying ferroptosis, including both GPX4-dependent and -independent antioxidant mechanisms. Additionally, we examine the involvement of ferroptosis in various pathological conditions, including cancer, neurodegenerative diseases, sepsis, ischemia–reperfusion injury, autoimmune disorders, and metabolic disorders. Specifically, we explore the role of ferroptosis in response to chemotherapy, radiotherapy, immunotherapy, nanotherapy, and targeted therapy. Furthermore, we discuss pharmacological strategies for modulating ferroptosis and potential biomarkers for monitoring this process. Lastly, we elucidate the interplay between ferroptosis and other forms of regulated cell death. Such insights hold promise for advancing our understanding of ferroptosis in the context of human health and disease.

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Identification of ZIP8-induced ferroptosis as a major type of cell death in monocytes under sepsis conditions

Cited by 5 publications

References 109 publications

STEAP3-SLC39A8-mediated microglia ferroptosis involved in neurotoxicity in rats after exposure to lead and cadmium combined

STEAP3-SLC39A8-mediated microglia ferroptosis involved in neurotoxicity in rats after exposure to lead and cadmium combined

The molecular underpinnings of female predominance in lupus

Ferroptosis: principles and significance in health and disease

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