Identification, structure, and phylogenetic relationships of a mitogen-activated protein kinase homologue from the parasitic protist Entamoeba histolytica

Ray, Deepshikha; Dutta, Suman; Banerjee, Sampali; Banerjee, Rahul; Raha, Sanghamitra

doi:10.1016/j.gene.2004.10.026

Cited by 13 publications

(12 citation statements)

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“…Recent studies confirmed that MAPKs are more ancient than previously thought. ERK has been recognized in the protist Dunaliella viridis [48], in yeasts [47] and in the parasite Entamoeba histolytica [49]. ERK variants are present in insects, like Drosophila , in reptiles and mammals.…”

Section: Discussionmentioning

confidence: 99%

A New Paradigm for MAPK: Structural Interactions of hERK1 with Mitochondria in HeLa Cells

et al. 2009

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Extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) are members of the MAPK family and participate in the transduction of stimuli in cellular responses. Their long-term actions are accomplished by promoting the expression of specific genes whereas faster responses are achieved by direct phosphorylation of downstream effectors located throughout the cell. In this study we determined that hERK1 translocates to the mitochondria of HeLa cells upon a proliferative stimulus. In the mitochondrial environment, hERK1 physically associates with (i) at least 5 mitochondrial proteins with functions related to transport (i.e. VDAC1), signalling, and metabolism; (ii) histones H2A and H4; and (iii) other cytosolic proteins. This work indicates for the first time the presence of diverse ERK-complexes in mitochondria and thus provides a new perspective for assessing the functions of ERK1 in the regulation of cellular signalling and trafficking in HeLa cells.

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Section: Discussionmentioning

confidence: 99%

A New Paradigm for MAPK: Structural Interactions of hERK1 with Mitochondria in HeLa Cells

et al. 2009

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“…ERK7 (MAPK15) is found in rat, mouse and zebrafish and recently the Dictyostelium erkB (ERK2) has been characterized as an erk7-ortholog [42,43]. Genome-based analyses revealed that human erk8 and rodent erk7 are orthologs [44].…”

Section: Erk7 Erk8 (Mapk15)mentioning

confidence: 99%

Functions of the MAPK family in vertebrate‐development

2006

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The mitogen activated protein kinase (MAPK) family, consisting of the extracellular signal regulated protein kinase, c-Jun amino terminal MAPK and p38 subfamilies, is conserved in evolution throughout the plant and animal kingdoms. These proteins have been implicated in diverse cellular processes including cell growth, migration, proliferation, differentiation, survival and development. Gene-targeting approaches in mice, chickens, frogs and zebrafish revealed crucial roles of MAPK in vertebrate development. Gene-disruption or -silencing often lead to lethal effects, therefore the zebrafish ex utero development provides an excellent in vivo model to study the function of MAPK in early embryogenesis. In this review, we summarize the current understanding of the MAPK family function in vertebrate-development and place this into the perspective of possibilities for future research.

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“…The E. histolytica EhMAPK gene encodes a putative MAPK with significant homology to human ERK8 [71]. We are not aware of any further MAPK analyses in this genus or of any reports of MAPK genes or function in Naegleria or Acanthamoeba .…”

Section: Phylum Sarcomastigophoramentioning

confidence: 99%

Parasite Mitogen-Activated Protein Kinases as Drug Discovery Targets to Treat Human Protozoan Pathogens

Brumlik

Pandeswara

Ludwig

et al. 2011

Journal of Signal Transduction

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Protozoan pathogens are a highly diverse group of unicellular organisms, several of which are significant human pathogens. One group of protozoan pathogens includes obligate intracellular parasites such as agents of malaria, leishmaniasis, babesiosis, and toxoplasmosis. The other group includes extracellular pathogens such as agents of giardiasis and amebiasis. An unfortunate unifying theme for most human protozoan pathogens is that highly effective treatments for them are generally lacking. We will review targeting protozoan mitogen-activated protein kinases (MAPKs) as a novel drug discovery approach towards developing better therapies, focusing on Plasmodia, Leishmania, and Toxoplasma, about which the most is known.

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Identification, structure, and phylogenetic relationships of a mitogen-activated protein kinase homologue from the parasitic protist Entamoeba histolytica

Cited by 13 publications

References 50 publications

A New Paradigm for MAPK: Structural Interactions of hERK1 with Mitochondria in HeLa Cells

A New Paradigm for MAPK: Structural Interactions of hERK1 with Mitochondria in HeLa Cells

Functions of the MAPK family in vertebrate‐development

Parasite Mitogen-Activated Protein Kinases as Drug Discovery Targets to Treat Human Protozoan Pathogens

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