Identifications of inhibitors of IgE production by human lymphocytes isolated from ‘Cha Chuukanbohon Nou 6’ tea leaves

Honma, Daiki; Tagashira, Motoyuki; Kanda, Tomomasa; Maeda‐Yamamoto, Mari

doi:10.1002/jsfa.3807

Cited by 5 publications

(5 citation statements)

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“…This unique cultivar is also rich in theogallin, one of the bioactive factors that inhibited thrombin-induced MRLC phosphorylation in HUVECs (Fig. 8) and a novel inhibitor of IgE production as a promising anti-allergic target [30]. These observations suggest that Nou-6 is an attractive green tea cultivar for ameliorating effects of stress and vascular function or for anti-allergic effects.…”

Section: Discussionmentioning

confidence: 90%

Metabolomics-Driven Nutraceutical Evaluation of Diverse Green Tea Cultivars

et al. 2011

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BackgroundGreen tea has various health promotion effects. Although there are numerous tea cultivars, little is known about the differences in their nutraceutical properties. Metabolic profiling techniques can provide information on the relationship between the metabolome and factors such as phenotype or quality. Here, we performed metabolomic analyses to explore the relationship between the metabolome and health-promoting attributes (bioactivity) of diverse Japanese green tea cultivars.Methodology/Principal FindingsWe investigated the ability of leaf extracts from 43 Japanese green tea cultivars to inhibit thrombin-induced phosphorylation of myosin regulatory light chain (MRLC) in human umbilical vein endothelial cells (HUVECs). This thrombin-induced phosphorylation is a potential hallmark of vascular endothelial dysfunction. Among the tested cultivars, Cha Chuukanbohon Nou-6 (Nou-6) and Sunrouge (SR) strongly inhibited MRLC phosphorylation. To evaluate the bioactivity of green tea cultivars using a metabolomics approach, the metabolite profiles of all tea extracts were determined by high-performance liquid chromatography-mass spectrometry (LC-MS). Multivariate statistical analyses, principal component analysis (PCA) and orthogonal partial least-squares-discriminant analysis (OPLS-DA), revealed differences among green tea cultivars with respect to their ability to inhibit MRLC phosphorylation. In the SR cultivar, polyphenols were associated with its unique metabolic profile and its bioactivity. In addition, using partial least-squares (PLS) regression analysis, we succeeded in constructing a reliable bioactivity-prediction model to predict the inhibitory effect of tea cultivars based on their metabolome. This model was based on certain identified metabolites that were associated with bioactivity. When added to an extract from the non-bioactive cultivar Yabukita, several metabolites enriched in SR were able to transform the extract into a bioactive extract.Conclusions/SignificanceOur findings suggest that metabolic profiling is a useful approach for nutraceutical evaluation of the health promotion effects of diverse tea cultivars. This may propose a novel strategy for functional food design.

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Section: Discussionmentioning

confidence: 90%

Metabolomics-Driven Nutraceutical Evaluation of Diverse Green Tea Cultivars

et al. 2011

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“…As shown in Table 2, the content of EGCG, EGCG3″Me, EGC and EC increased with progressive growth stages of the tea leaf; however, the content of ECG, CAF, ST and THEO decreased in the first crop season. It was found previously that ST or THEO showed an anti‐allergic effect through the suppression of immunoglobulin E production of B cells 29, 30…”

Section: Resultsmentioning

confidence: 98%

Chemical analysis and acetylcholinesterase inhibitory effect of anthocyanin‐rich red leaf tea (cv. Sunrouge)

et al. 2012

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“…されている (33) ．G-ストリクチニンは茶中間母本農 6 号に多い成分であり (33) ，茶葉乾物重量あたり約 8％含有しているが，一般に多く流通する緑茶には含まれてない．テオガリンとストリクチニンについては最も多く流通している「やぶきた」にも含まれるが，テオガリンは 1％以下，ストリクチニンは 1％前後である (33) 抑制することが報告されている (35) ．ちなみに，没食子酸は 67LR に作用しないことが確認されている (22) ．生体レベルでは，没食子酸を摂取することにより，デキストラン硫酸ナトリウム誘発マウス潰瘍性大腸炎の軽減，家畜として飼育されている子豚の下痢の低下，雛鳥の空腸 (栄養吸収領域)の形態が改善されるなどの抗炎症作用による腸内環境改善効果が報告されている (36)(37)(38) ．緑茶の淹れ方と免疫機能性…”

Section: Egc は Trpm2(transient Receptor Potentialunclassified

The Immune Effects of Green Tea Components: Functional Alterations Due to Extraction Temperature

Monobe¹

2021

KAGAKU TO SEIBUTSU

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Identifications of inhibitors of IgE production by human lymphocytes isolated from ‘Cha Chuukanbohon Nou 6’ tea leaves

Abstract: The results suggest Cha Chuukanbohon Nou 6 to be the basis of an antiallergic beverage.

Cited by 5 publications

References 59 publications

Metabolomics-Driven Nutraceutical Evaluation of Diverse Green Tea Cultivars

Metabolomics-Driven Nutraceutical Evaluation of Diverse Green Tea Cultivars

Chemical analysis and acetylcholinesterase inhibitory effect of anthocyanin‐rich red leaf tea (cv. Sunrouge)

The Immune Effects of Green Tea Components: Functional Alterations Due to Extraction Temperature

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