Identifications of polyphyletic variants in acute hepatitis suggest an underdiagnosed circulation of hepatitis E virus in Argentina

Munné, María Silvina; Altabert, Nancy; Vladimirsky, Sara; Moreiro, Rita; Mares, Lucio Oscar Otegui; Soto, Sonia; Brajterman, Leonardo; Castro, Raúl; González, Jorge

doi:10.1016/j.jcv.2011.06.015

Cited by 22 publications

(25 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding the detection of anti-HEV IgG in patients with non-A, non-B, non-C hepatitis in other countries, the prevalence found in this study was similar to those observed in regions with low endemicity in the Americas, such as Argentina (3.0%; 95% CI: 1.3-6.1) (Munné et al 2011), Colombia (7.5%; 95% CI: 5.1-11.0) (Peláez et al 2014) and the US (4.9%; 95% CI: 2.5-9.1) (Karetnyi et al 1999), as well as in Europe, including Hungary (7.2%; 95% CI: 4.5-11.2) (Haagsman et al 2007), the Netherlands (5.8%; 95% CI: 3.6-9.2) (Herremans et al 2007) and Spain (5.6%; 95% CI: 2.1-13.1) (Buti et al 1995). On the other hand, among hospitalised patients with acute non-A, non-B, non-C hepatitis in Italy, anti-HEV IgG rates were higher (26.6%; 95% CI: 23.2-30.2 and 48.1%; 95% CI: 44.2-62.2) (Romanò et al 2011, Candido et al 2012).…”

Section: Discussionsupporting

confidence: 86%

“…On the other hand, anti-HEV IgM was detected in 27 out 552 (4.9%) samples from patients clinically suspected of hepatitis E analysed between the years 2006-2013 (Passos-Castilho et al 2015). In other American and European countries, anti-HEV IgM rates ranged from 1.1-4.8% (Haagsman et al 2007, Munné et al 2011) except in groups with specific characteristics such as patients from outbreaks of acute viral hepatitis in Cuba (Lay et al 2008) or hospitalised patients in Chile (Hurtado et al 2005) and Italy (Romanò et al 2011, Candido et al 2012), where those rates were substantially higher (ranging from 20.6-40.3%).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil

Freitas

Santana

Silva

et al. 2016

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

Hepatitis E virus (HEV) infection has a worldwide distribution and represents an important cause of acute hepatitis. This study aims to investigate the occurrence of HEV infection and factors associated with this infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil. From April 2012 to October 2014, a cross-sectional study was conducted among 379 patients with acute non-A, non-B, non-C hepatitis in the City of Goiania, Central Brazil. Serum samples of all patients were tested for serological markers of HEV infection (anti-HEV IgM and IgG) by ELISA. Positive samples were confirmed using immunoblot test. Anti-HEV IgM and IgG positive samples were tested for HEV RNA. Of the 379 serum samples, one (0.3%) and 20 (5.3%) were positive for anti-HEV IgM and IgG, respectively. HEV RNA was not found in any sample positive for IgM and/or IgG anti-HEV. After multivariate analysis, low education level was independently associated with HEV seropositivity (p = 0.005), as well as living in rural area, with a borderline p-value (p = 0.056). In conclusion, HEV may be responsible for sporadic self-limited cases of acute hepatitis in Central Brazil.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil

Freitas

Santana

Silva

et al. 2016

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

“…According to the phylogenetic reconstruction reported in Munné´s work, the variants described by Schlauder et al (2000) were reassigned within the genotype 3. Recently, in a study conducted to better understand the molecular epidemiology of HEV infection in Argentina, the co-circulation of polyphyletic variants was clearly demonstrated by phylogenetic analysis of the 287-bp region within ORF 1 and a small sequence of the ORF 2 (capsid gene) (Munné et al 2011). In fourteen out of fifteen diagnosed cases of acute HEV infection included in this study, HEV genotype 3 isolates were detected and strains of subtypes 3a, 3b and 3i were identified.…”

Section: Molecular Epidemiologymentioning

confidence: 81%

“…Genotype 1 consists of epidemic strains and has been reported in various countries in Asia (Bangladesh, China, India, Vietnam, Pakistan, Nepal) and Africa (Chad, Egypt, Sudan, South Africa), Cuba and, recently, Argentina (an imported case from Asia) and Venezuela (Okamoto, 2007;Montalvo et al 2008;Munné et al 2011;García et al 2012). Genotype 2 sequences were first reported from an epidemic in Mexico (Huang et al 1992) and subsequently identified from endemic cases in several African countries (Buisson et al 2000;Maila et al 2004;Nicand et al 2005).…”

Section: Geographical Distributionmentioning

confidence: 99%

Molecular Epidemiology of Hepatitis E Virus (Hev) in South America: Current Status

Mirazo¹,

Ramos²,

Arbiza³

2012

VR&R

View full text Add to dashboard Cite

Hepatitis E virus (HEV) is a common causative agent of acute hepatitis in many developing countries where standards of sanitation and hygiene are poor. HEV is transmitted primarily by the fecal-oral route. However, zoonotic trasmission from animal reservoirs to human by consumption of raw or undercooked meat has also been suggested. In endemic areas, HEV infection occurs as large waterborne epidemics and/or small outbreaks. Sporadic cases of HEV infection have also been reported in developed countries, where its occurrence is not always associated with travel to highly endemic areas. HEV mammalian isolates are classifi ed into four genotypes 1-4, which appear to have a specifi c host range and geographical distribution. The epidemiology of HEV in South America seems to be complex and seroprevalence in human and domestic pigs diff ers both among populations within the same countries and between countries. Additionally, HEV strains have been detected and molecularly characterized and genotype 3 is the most frequently genotype found in the region. Moreover, except for two strains isolated from autochthonous cases of acute hepatitis that occurred in Venezuela and belonged to genotype 1, all sequences detected in South America were classifi ed as within genotype 3. Our understanding of HEV epidemiology has undergone major changes in recent years and despite the fact that several attempts to shed light over the epidemiology of this infection have been carried out in South America, data about the molecular characterization of HEV isolates is still lacking and further investigation is needed. This review summarizes the current status of HEV molecular epidemiology from a regional point of view.

show abstract

“…Arankalle, et al, describieron una seroprevalencia de la infección por HEV de 8 % en niños menores de 10 años, comparada con 40 % en adultos mayores, en población asintomática de la India (54); por otra parte, Assis, et al, demostraron la presencia del marcador IgG anti-HEV en el 4,5 % de los niños de 2 a 9 años de edad del municipio de Mato Grosso, Brasil (30). En otro estudio, Munne, et al, encontraron una frecuencia de IgM anti-HEV de 8,5 % en niños argentinos con hepatitis viral aguda (51,52). Es de anotar que India es un país endémico, y que Argentina y Brasil son países con un patrón no endémico para la infección por HEV.…”

Section: Discussionunclassified

Infección por el virus de la hepatitis E en pacientes con diagnóstico clínico de hepatitis viral en Colombia

et al. 2014

View full text Add to dashboard Cite

Identifications of polyphyletic variants in acute hepatitis suggest an underdiagnosed circulation of hepatitis E virus in Argentina

Cited by 22 publications

References 28 publications

Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil

Hepatitis E virus infection in patients with acute non-A, non-B, non-C hepatitis in Central Brazil

Molecular Epidemiology of Hepatitis E Virus (Hev) in South America: Current Status

Infección por el virus de la hepatitis E en pacientes con diagnóstico clínico de hepatitis viral en Colombia

Contact Info

Product

Resources

About