Identifying a Loss-in-Weight Feeder Design Space Based on Performance and Material Properties

Li, Tianyi; Scicolone, James V.; Sánchez, Eric; Muzzio, Fernando J.

doi:10.1007/s12247-019-09394-4

Cited by 13 publications

(8 citation statements)

References 23 publications

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“…The most common feeders, being used for dosing processes within continuous pharmaceutical manufacturing, are the loss-in-weight feeders (LIW) [5, 9,24,25,26,27,39,40,47,60,67,117,119,124,125]. The general setup of such a loss-in-weight-feeder with its three main components is depicted in Figure 4.…”

Section: Theoretical Aspectsmentioning

confidence: 99%

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Continuous twin screw granulation and fluid bed drying: A mechanistic scaling approach focusing optimal tablet properties

Menth

Maus

Wagner

2020

International Journal of Pharmaceutics

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Section: Theoretical Aspectsmentioning

confidence: 99%

“…Loss-in-weight-feeders offer a broad variance of accessories in terms of screw and hopper design (see Figure 5) [9,24,40,60,124,125] to optimize powder feed-rate and the emptying behaviour of the hopper for various powders.…”

Section: Powder Characterisation Of Starting Materials Using Volumetric Dosingmentioning

confidence: 99%

Continuous twin screw granulation and fluid bed drying: A mechanistic scaling approach focusing optimal tablet properties

Menth

Maus

Wagner

2020

International Journal of Pharmaceutics

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“…However, some studies (14,15) indicate that the variability and disturbance during the feeding operation can affect the performance of downstream unit operations and the final product quality. To control the feeding performance of LIW feeders, the feeder tooling selection was matched to the material properties (9,12,13,16,17). In addition, individual feeder control strategies have been developed to reduce the variability of the fed material's concentration (6,18).…”

Section: Introductionmentioning

confidence: 99%

“…Loss-in-weight (LIW) feeders are frequently used in the pharmaceutical CM process to maintain consistent feeding into subsequent unit operations. The principle of LIW feeding involves the constant monitoring of the mass (i.e., weight) of material in the feeder while discharging and constantly adjusting the rate of discharging to maintain a mass flow rate ( 9 ). The mass of the feeder is monitored via a balance under the feeding unit.…”

Section: Introductionmentioning

confidence: 99%

“…The feeding range of feeders depends on the feeder’s size and tooling (e.g., screws and screens) and the material properties ( 9 ). Although the use of feeders is well established in many industries and has been successfully applied in various processes, there are limitations as to the specific types of materials and the minimum feasible feed rate.…”

Section: Introductionmentioning

confidence: 99%

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Development of a Controlled Continuous Low-Dose Feeding Process

et al. 2021

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This paper proposes a feed rate control strategy for a novel volumetric micro-feeder, which can accomplish low-dose feeding of pharmaceutical raw materials with significantly different powder properties. The developed feed-forward control strategy enables a constant feed rate with a minimum deviation from the set-point, even for materials that are typically difficult to accurately feed (e.g., due to high cohesion or low density) using conventional continuous feeders. Density variations observed during the feeding process were characterized via a displacement feed factor profile for each powder. The characterized effective displacement density profile was applied in the micro-feeder system to proactively control the feed rate by manipulating the powder displacement rate (i.e., computing the feed rate from the powder displacement rate). Based on the displacement feed factor profile, the feed rate can be predicted during the feeding process and at any feed rate set-point. Three pharmaceutically relevant materials were used for the micro-feeder evaluation: di-calcium phosphate (large-particle system, high density), croscarmellose sodium (small-particle system, medium density), and barium sulfate (very small-particle <10 μm, high density). A significant improvement in the feeding performance was achieved for all investigated materials. The feed rate deviation from the set-point and its relative standard deviation were minimal compared to operations without the control strategy.

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Improving Feedability of Highly Adhesive Active Pharmaceutical Ingredients by Silication

et al. 2020

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Identifying a Loss-in-Weight Feeder Design Space Based on Performance and Material Properties

Cited by 13 publications

References 23 publications

Continuous twin screw granulation and fluid bed drying: A mechanistic scaling approach focusing optimal tablet properties

Continuous twin screw granulation and fluid bed drying: A mechanistic scaling approach focusing optimal tablet properties

Development of a Controlled Continuous Low-Dose Feeding Process

Improving Feedability of Highly Adhesive Active Pharmaceutical Ingredients by Silication

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