Identifying Adverse Events Using International Classification of Diseases, Tenth Revision Y Codes in Korea: A Cross-sectional Study

Abstract

ObjectivesThe use of administrative data is an affordable alternative to conducting a difficult large-scale medical-record review to estimate the scale of adverse events. We identified adverse events from 2002 to 2013 on the national level in Korea, using International Classification of Diseases, tenth revision (ICD-10) Y codes.MethodsWe used data from the National Health Insurance Service-National Sample Cohort (NHIS-NSC). We relied on medical treatment databases to extract information on ICD-10 Y codes from each participant in the NHIS-NSC. We classified adverse events in the ICD-10 Y codes into 6 types: those related to drugs, transfusions, and fluids; those related to vaccines and immunoglobulin; those related to surgery and procedures; those related to infections; those related to devices; and others.ResultsOver 12 years, a total of 20 817 adverse events were identified using ICD-10 Y codes, and the estimated total adverse event rate was 0.20%. Between 2002 and 2013, the total number of such events increased by 131.3%, from 1366 in 2002 to 3159 in 2013. The total rate increased by 103.9%, from 0.17% in 2002 to 0.35% in 2013. Events related to drugs, transfusions, and fluids were the most common (19 446, 93.4%), followed by those related to surgery and procedures (1209, 5.8%) and those related to vaccines and immunoglobulin (72, 0.3%).ConclusionsBased on a comparison with the results of other studies, the total adverse event rate in this study was significantly underestimated. Improving coding practices for ICD-10 Y codes is necessary to precisely monitor the scale of adverse events in Korea.

Códigos da classificação internacional de doenças como rastreadores de eventos adversos a medicamentos

“…Quanto ao local de origem dos estudos selecionados, onze (33,3%) foram realizados na Europa 2,4,7,23-30 , oito (24,2%) na Oceania 2,22,[31][32][33][34][35][36] , sete (21,2%) na América do Norte [37][38][39][40][41][42][43] , seis (18,2%) na América do Sul 9-11,44-46 e um (3,0%) na Ásia 47 . Os países com maior número de estudos foram Austrália (n=7), Brasil (n=6) e Inglaterra (n=6).…”

“…Os países com maior número de estudos foram Austrália (n=7), Brasil (n=6) e Inglaterra (n=6). Quanto ao desfecho principal, 15 (45,4%) estudos avaliaram EAM (em geral) 9,11,24,25,31,33,[38][39][40][46][47][48][49][50] , 14 (42,4%) avaliaram somente RAM 1,2,7,22,23,[26][27][28][29][30]35,36,44,51 e quatro (12,1%) especificamente intoxicações com medicamentos 10,40-42 (Quadro 3).…”

“…A maioria dos estudos utilizou delineamento transversal 1,2,7,9-11,22,23,25-31,36,37,41-44,47,49 (87,8%). Os dados administrativos hospitalares foi a fonte mais explorada nos estudos (75,7%) 2,7,9,22,24-26, [28][29][30]32,33,35,36,38,40,43,44,47,51,52 , em seguida os dados de mortalidade (24,4%) 10,22,23,31,40,42,47 , dados de farmacovigilância (15,1%) 7,28,32,33,37 , e da atenção básica ou ambulatorial (6,0%) 43 (Quadro 3).…”

Use of ICD‐10‐CM T codes in hospital claims data to identify adverse drug events in Taiwan

“…Saff et al studied a broad set of ICD‐9‐CM codes and E codes to identify allergic drug reactions in hospitalized patients 10 . Ock et al 27 reported that ICD‐10 Y codes are relatively useful in identifying adverse events related to drugs, transfusions and fluids in Korea. Stausberg et al 28,29 used ICD‐10 and German Modification (ICD‐10‐GM) codes to detect ADEs and reported that the prevalence rate of these ADEs codes in Germany was approximately 4.8%.…”

“…On the basis of this classification, these ICD‐10 codes were selected for evaluation to represent the occurrence of ADEs. Following previous studies, 10,11,27,28 the external injury cause codes of ICD‐10‐CM in Taiwan include T codes that are similar to ICD‐10 Y codes, and we attempted to identify ADEs using ICD‐10‐CM T codes. The current study might provide insight because it is the first study to detect ADEs using ICD‐10‐CM T codes in Taiwan.…”