Identifying and treating cognitive impairment in bipolar disorder

Goldberg, Joseph F.; Chengappa, KN Roy

doi:10.1111/j.1399-5618.2009.00716.x

Cited by 149 publications

(116 citation statements)

References 102 publications

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“…Bipolar disorder is a major psychiatric disorder associated with brain atrophy [1] and neurocognitive impairment [2]. Increasing evidence supports the involvement of immunomodulation in the pathophysiology of bipolar disorder [3,4,5], along with glucose and lipid metabolism [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

The Link between High-Sensitivity C-Reactive Protein and Orbitofrontal Cortex in Euthymic Bipolar Disorder

Chung

Huang

et al. 2013

Neuropsychobiology

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Objective: C-reactive protein (CRP), a marker of underlying low-grade inflammation, has been associated with the pathophysiology of bipolar disorder. Additionally, bipolar disorder may be accompanied by functional or structural cerebral alterations. We attempted to discover whether serum high-sensitivity CRP (hs-CRP) levels are linked to the structural volume change of a specific brain region along with cognitive performance. Methods: We recruited 17 physically healthy patients with bipolar I disorder (DSM-IV), aged 18-45 years and euthymic, to undergo the Wisconsin Card Sorting Test (WCST) and volumetric magnetic resonance imaging at 1.5 T. The analytic method was based on the hidden Markov random field model with an expectation-maximization algorithm, and the volume of each brain region was presented as a percentage of the total intracranial volume. Results: Among the various regions, only the orbitofrontal cortex had a significantly negative correlation with serum hs-CRP levels after adjustment for age and gender (left and right orbitofrontal cortex: r = -0.62, p < 0.01, and r = -0.67, p < 0.005, respectively). Regarding cognitive function, poor WCST performance was also associated with certain subregions of the orbitofrontal cortex. Conclusion: Elevation of serum hs-CRP levels, an indicator of inflammation, may be associated with reduced volume of the orbitofrontal cortex. Persistent inflammation in the euthymic phase of bipolar disorder may involve the pathogenesis or pathophysiology of alteration of the frontal pathway.

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Section: Introductionmentioning

confidence: 99%

The Link between High-Sensitivity C-Reactive Protein and Orbitofrontal Cortex in Euthymic Bipolar Disorder

Chung

Huang

et al. 2013

Neuropsychobiology

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“…In view of previous findings that rejection sensitivity is more prevalent in patients with bipolar rather than unipolar depression, we wanted to investigate rejection cue words in a euthymic and mildly depressed BD sample. Secondly, we hypothesized that individuals with BD would show poorer performance on verbal memory, attention and executive functions than a control group as has been detected by several previous studies [31][32][33][34] . Thirdly, we hoped to expand the knowledge of AM specificity and its relationship to neuropsychological performance in BD [8] .…”

Section: Bipolar Disorder · Autobiographical Memory · Neuropsychologimentioning

confidence: 96%

“…A considerable number of studies observed cognitive deficits in individuals with BD [7,29,30] . In particular, the proposal of deficits in executive functions in BD has gathered some empirical support to date [31][32][33][34] .…”

Section: Bipolar Disorder · Autobiographical Memory · Neuropsychologimentioning

confidence: 99%

Autobiographical Memory in Bipolar Disorder and Its Link to Neuropsychological Functioning

Quinlivan

Dallacker

Renneberg³

et al. 2017

Psychopathology

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Objective: The aim of this study was to examine the specificity of autobiographical memory (AM) in bipolar disorder (BD) and to investigate the association between AM and neuropsychological functions. Method: Twenty bipolar patients and 22 matched healthy controls (HCs) were included in this study. AM was assessed with an extended version of the Autobiographical Memory Test (AMT) including rejection cue words. A neuropsychological test battery was used to examine verbal memory, executive functions, and attention. Results: Across both groups, the number of specific memories in the AMT was significantly smaller in response to rejection cue words and positive cue words than in response to negative cue words. Participants with BD and HCs did not differ significantly in neuropsychological measures. Across both groups, scores of verbal memory, executive functions, and attention were significantly correlated with specificity of retrieved memories. Limitations: Although our clinical sample consisted of clinically stable outpatients, 6 out of 20 patients were not rated as euthymic but as mildly depressed. All BD patients were medicated. Conclusion: Contrary to previous results, patients with BD did not differ in the number of specific memories compared to an HC group. Our findings suggest that neuropsychological functioning is associated with AMT specificity. Further research is required to gain a better understanding of the underlying mechanisms which may influence the ease of memory retrieval.

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“…Such a differentiation requires a comprehensive assessment, on the basis of knowledge of those neurocognitive domains most affected by specifi c medications (Goldberg and Chengappa 2009 ).…”

Section: The Effect Of Medicationmentioning

confidence: 99%

Neurocognitive Functioning in Bipolar Disorder: A Comprehensive Review of Recent Data

Fountoulakis

2014

Bipolar Disorder

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Identifying and treating cognitive impairment in bipolar disorder

Abstract: Circumscribed cognitive deficits may be both iatrogenic and intrinsic to bipolar disorder. Optimal management hinges on a knowledge of illness-specific cognitive domains as well as of the beneficial or adverse cognitive profiles of common psychotropic medications.

Cited by 149 publications

References 102 publications

The Link between High-Sensitivity C-Reactive Protein and Orbitofrontal Cortex in Euthymic Bipolar Disorder

The Link between High-Sensitivity C-Reactive Protein and Orbitofrontal Cortex in Euthymic Bipolar Disorder

Autobiographical Memory in Bipolar Disorder and Its Link to Neuropsychological Functioning

Neurocognitive Functioning in Bipolar Disorder: A Comprehensive Review of Recent Data

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