Identifying Antigen-Specific T Cells in ANCA-Associated Vasculitis: A Glimpse of the Future?

Shochet, Lani; Kitching, A. Richard

doi:10.1681/asn.2022060668

Cited by 1 publication

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ANCA-associated vasculitis (AAV) is a group of autoimmune diseases affecting small-sized vessels, encompassing microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), and eosinophilic granulomatosis with polyangiitis (EGPA) ( 51 – 53 ). Similar to SLE, the etiology of AAV is still not fully understood, but generally considered to be the result of multiple factors, including genetic susceptibility (e.g., MHC II genotypes) and environmental factors, such as pathogens and drugs ( 54 – 57 ). All AAV can affect the kidney and induce cGN.…”

Section: T Rm Cells In Anca-associated Gnmentioning

confidence: 99%

“…Furthermore, in the glomeruli with segmental necrosis and cellular crescents, active glomerular lesions correlate with intraglomerular T cells ( 59 ). In AAV patients, MPO- and PR3-specific CD4 + T cells were identified, showing a decreased TCR diversity and clonal expansion ( 55 – 57 ). These autoreactive T cells show memory T cell phenotype and secrete proinflammatory cytokines including IL-17A ( 55 , 60 ).…”

Section: T Rm Cells In Anca-associated Gnmentioning

confidence: 99%

See 1 more Smart Citation

Tissue-resident memory T cells in renal autoimmune diseases

2023

View full text Add to dashboard Cite

The discovery of tissue-resident memory T cells (TRM cells) reinterpreted the potential of human tissue-specific immunity. Following T cell receptor (TCR) activation and clonal expansion, effector T cells migrate to peripheral tissues where they remain long-term and differentiate to TRM cells after antigen clearance. This allows for prompt immunological responses upon antigen re-encounter. In addition to their protective properties in acute infections, recent studies have revealed that TRM cells might lead to aggravation of autoimmune diseases, such as lupus nephritis (LN) and anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN). These diseases present as proliferative and crescentic glomerulonephritis (cGN), which is a life-threatening condition leading to end-stage renal disease (ESRD) if left untreated. A better understanding of renal TRM cells might lead to identifying new therapeutic targets for relapsing autoimmune diseases of the kidney. In this review, we summarize the current knowledge of renal TRM cells and discuss their potential pathophysiological roles in renal autoimmune diseases.

show abstract