Identifying brain regions associated with the neuropathology of chronic low back pain: a resting-state amplitude of low-frequency fluctuation study

Zhang, Binlong; Jung, Minyoung; Tu, Yiheng; Gollub, Randy L.; Lang, Courtney; Ortiz, Ana; Park, Joel; Wilson, Georgia; Gerber, Jessica; Mawla, Ishtiaq; Chan, Suk-Tak; Wasan, Ajay D.; Edwards, Robert R.; Lee, Jeungchan; Napadow, Vitaly; Kaptchuk, Ted J.; Rosen, Bruce R.; Kong, Jian

doi:10.1016/j.bja.2019.02.021

Cited by 85 publications

(86 citation statements)

References 40 publications

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“…The increased spontaneous activity in this nucleus has been reported in the context of some mental disorders ( 36 ). Furthermore, our data suggest that regional low-frequency oscillations of this region are sensitive to chronic pain, which are consistent with previous studies ( 15 , 37 ). Overall, in older patients with KOA, altered ALFF in these important brain regions may contribute to the prevalence of memory function decline from neuropsychological assessment in this study and chronic pain in previous studies ( 38 – 41 ).…”

Section: Discussionsupporting

confidence: 93%

“…The SMA plays a key role in movement planning and initiation, especially in self-initiated movements ( 54 ). The increased FC in the SMA may be a compensatory effect for poor motor function of the KOA patients, which was similar to previous studies that demonstrated that the activation of SMA may be caused by the disease itself or by patients' altered motor functions ( 15 , 37 , 55 ). This indicates that knee arthroplasty can improve joint mobility and may contribute to the recovery of disordered brain function.…”

Section: Discussionsupporting

confidence: 89%

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Altered Intrinsic Brain Activity and Functional Connectivity Before and After Knee Arthroplasty in the Elderly: A Resting-State fMRI Study

et al. 2020

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Objective: This study aimed to investigate the brain functional alterations with resting-state functional magnetic resonance imaging (rs-fMRI) in older patients with knee osteoarthritis (KOA) before and after total knee arthroplasty (TKA) and to assess the causal relationship of the brain function and neuropsychological changes. Methods: We performed rs-fMRI to investigate brain function of 23 patients aged ≥65 with KOA and 23 healthy matched controls. Of the KOA patients, 15 completed postoperative rs-fMRI examinations. Analyzes of the amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) were used to estimate differences in brain functional parameters between KOA patients, postoperative patients, and the controls. The relationship between changes of pre- and post-surgical status in ALFF and neuropsychological test results was analyzed. Results: Compared with the controls, all patients with KOA exhibited decreased ALFF in the default mode network (bilateral angular gyrus, precuneus gyrus, medial superior frontal gyrus) and increased ALFF in the bilateral amygdala and cerebellum posterior lobe before surgery ( P < 0.001). Altered ALFF persisted in the same brain regions 1 week postoperatively. The decreased ALFF in the left precuneus gyrus and middle temporal gyrus was found after surgery when compared with preoperative data ( P < 0.01). Preoperatively, the KOA patients exhibited increased FC between the left precuneus gyrus and the right supplementary motor area compared to the controls ( P < 0.001), but this connectivity became no significant difference after TKA. The left Cerebelum_9 was found to have decreased FC with the right precuneus gyrus postoperatively ( P < 0.001) although this was not significantly different before surgery. The significantly altered ALFF values were not correlated with changes in cognitive assessment scores. Conclusion: In older patients with end-stage KOA, functional alterations in important brain regions were detected with the persistence and further changes observed at an early stage after knee replacement. Our data further our understanding of brain functional abnormalities and cognitive impairment in older patients following knee replacement, which may provide therapeutic targets for preventive/treatment strategy to be developed. Trial registration: Clinical Trial Registration: http://www.chictr.org.cn/index.aspx , ChiCTR1800016437; Registered June 1, 2018.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Altered Intrinsic Brain Activity and Functional Connectivity Before and After Knee Arthroplasty in the Elderly: A Resting-State fMRI Study

et al. 2020

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“…As a key region of the limbic system, default mode network, and descending pain modulation system, the involvement of the rACC in the pathophysiology of chronic pain has been well documented [3,30,[43][44][45][46] . Previous studies have suggested close functional connectivity between the PAG, a key region of the descending pain modulation system, and the rACC [47] , and alterations in PAG-rACC functional connectivity in patients with fibromyalgia [3] .…”

Section: Discussionmentioning

confidence: 99%

“…Theoretically, brain regions that show structural/functional differences in fibromyalgia patients compared to HC's may be used as potential biomarkers for distinguishing fibromyalgia patients from HC's. Additionally, brain regions that are sensitive to pain intensity changes may have potential for fibromyalgia severity monitoring and may act as an objective measurement for treatment response [30] .…”

Section: Introductionmentioning

confidence: 99%

Altered hypothalamus functional connectivity with limbic system in fibromyalgia and the modulation effect of intervention

Kong¹,

Huang

Liu

et al. 2020

Preprint

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Background: This study aims to investigate the resting state functional connectivity (rsFC) changes of the hypothalamus in Fibromyalgia patients and the modulation effect of effective treatments. Methods: Fibromyalgia patients and matched healthy controls (HC’s) were recruited. Resting state fMRI data were collected from fibromyalgia patients before and after a 12-week Tai Chi intervention and once from HC’s. Results: Data analysis showed that fibromyalgia patients displayed significantly decreased medial hypothalamus (MH) rsFC with the thalamus and amygdala when compared to HC’s at baseline. After the intervention, fibromyalgia patients showed increased (normalized) MH rsFC in the thalamus and amygdala. Effective connectivity analysis showed disrupted MH and thalamus interaction in fibromyalgia, which nonetheless could be partially restored by Tai Chi. Conclusions: Elucidating the role of the diencephalon and limbic system in the pathophysiology and development of fibromyalgia may facilitate the development of new treatment methods for this prevalent disorder. Trial registration: Trial registration ClinicalTrials.gov Identifier: NCT02407665. Registered 3 April 2015 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02407665

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“…Resting-state functional magnetic resonance imaging (rs-fMRI), widely used in chronic pain diseases [11][12][13][14][15], is an effective tool to evaluate the intrinsic neural activity of the human brain [16,17]. The rs-fMRI analysis methods mainly include amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo) [9], and functional connectivity (FC) [10].…”

Section: Introductionmentioning

confidence: 99%

Altered intrinsic brain activity and regional cerebral blood flow in patients with chronic neck and shoulder pain

2020

Pol J Radiol

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Purpose: To identify the changes of intrinsic brain activity and regional cerebral blood flow in patients with chronic neck and shoulder pain (CNSP) by using amplitude of low-frequency fluctuation (ALFF) analysis and arterial spin labelling study. Material and methods: In total, 28 CNSP patients and 25 age-matched and sex-matched healthy controls (HCs) participated in the study. Resting-state functional magnetic resonance imaging (rs-fMRI) and arterial spin labelling (ASL) MRI were acquired. Correlations between ALFF and cerebral blood flow (CBF) were analysed. Subsequently, the differences in ALFF and CBF were compared in the two groups. Finally, the visual analogue scale (VAS) was also assessed in the CNSP group. Results: Compared with HCs, CNSP patients showed significantly abnormal ALFF and CBF in several brain regions, including the cerebellum posterior lobe, middle orbitofrontal gyrus, medial superior frontal gyrus, middle temporal gyrus, precuneus, cingulate gyrus, middle occipital gyrus, middle frontal gyrus, postcentral gyrus, precentral gyrus, and superior parietal gyrus. Correlation analysis showed that the ALFF value of the medial superior frontal gyrus positively correlated with the VAS score. However, no correlation was found between the CBF values and the VAS score. Conclusions: The altered ALFF and CBF values in CNSP patients were observed in different pain-related brain regions that were involved in pain modulation and perception. The combination of rs-fMRI and ASL MRI might provide complementary information for increasing our understanding of the neuropathology in CNSP.

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Identifying brain regions associated with the neuropathology of chronic low back pain: a resting-state amplitude of low-frequency fluctuation study

Cited by 85 publications

References 40 publications

Altered Intrinsic Brain Activity and Functional Connectivity Before and After Knee Arthroplasty in the Elderly: A Resting-State fMRI Study

Altered Intrinsic Brain Activity and Functional Connectivity Before and After Knee Arthroplasty in the Elderly: A Resting-State fMRI Study

Altered hypothalamus functional connectivity with limbic system in fibromyalgia and the modulation effect of intervention

Altered intrinsic brain activity and regional cerebral blood flow in patients with chronic neck and shoulder pain

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