2023
DOI: 10.3389/fonc.2023.1207695
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Identifying childhood leukemia with an excess of hematological malignancies in first-degree relatives in Brazil

Abstract: BackgroundFamilial aggregation in childhood leukemia is associated with epidemiological and genomic factors. Albeit epidemiological studies on the familial history of hematological malignancies (FHHMs) are scarce, genome-wide studies have identified inherited gene variants associated with leukemia risk. We revisited a dataset of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) patients to explore the familial aggregation of malignancies among their relatives.MethodsA series of 5,878 childhoo… Show more

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