Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses

Maarifi, Ghizlane; Martin, Marie-France; Zebboudj, Abderezak; Boulay, Aude; Nouaux, Pierre; Fernandez, Juliette; Lagisquet, Justine; Garcin, Dominique; Gaudin, Raphaël; Arhel, Nathalie J.; Nisole, Sébastien

doi:10.1016/j.chembiol.2022.05.009

Cited by 11 publications

(14 citation statements)

References 56 publications

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“…IRF1 is a protein found predominantly in the nucleus in the resting state 52 , 54 . The levels of production of this protein regulate its activity 56 , 58 – 60 .…”

Section: Resultsmentioning

confidence: 99%

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Rosain

Neehus²,

Manry³

et al. 2023

Cell

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“…IRF1 is a protein found predominantly in the nucleus in the resting state 52 , 54 . The levels of production of this protein regulate its activity 56 , 58 – 60 .…”

Section: Resultsmentioning

confidence: 99%

Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Rosain

Neehus²,

Manry³

et al. 2023

Cell

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“…Although Axl’s involvement in tumor progression has been known for many years, different drugs targeting this receptor have already been developed and commercialized, fostering studies about their repurposing in COVID-19 management. As preclinical studies using Axl inhibitors such as bemcentinib and gilteritinib showed promising results [ 84 , 85 , 86 , 87 , 95 ], bemcentinib is under clinical trials to evaluate its effectiveness in treating SARS-CoV-2 infection [ 88 , 89 ], while it has been reported that gilteritinib administration in an acute myeloid leukemia patient ameliorated COVID-19 symptoms [ 90 ].…”

Section: Axl Role In Sars-cov-2 Infectionmentioning

confidence: 99%

Gas6/TAM Axis Involvement in Modulating Inflammation and Fibrosis in COVID-19 Patients

Rizzi

Tonello

D’Onghia

et al. 2023

IJMS

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Gas6 (growth arrest-specific gene 6) is a widely expressed vitamin K-dependent protein that is involved in many biological processes such as homeostatic regulation, inflammation and repair/fibrotic processes. It is known that it is the main ligand of TAMs, a tyrosine kinase receptor family of three members, namely MerTK, Tyro-3 and Axl, for which it displays the highest affinity. Gas6/TAM axis activation is known to be involved in modulating inflammatory responses as well as fibrotic evolution in many different pathological conditions. Due to the rapidly evolving COVID-19 pandemic, this review will focus on Gas6/TAM axis activation in SARS-CoV-2 infection, where de-regulated inflammatory responses and fibrosis represent a relevant feature of severe disease manifestation. Furthermore, this review will highlight the most recent scientific evidence supporting an unsuspected role of Axl as a SARS-CoV-2 infection driver, and the potential therapeutic advantages of the use of existing Axl inhibitors in COVID-19 management. From a physiological point of view, the Gas6/TAM axis plays a dual role, fostering the tissue repair processes or leading to organ damage and loss of function, depending on the prevalence of its anti-inflammatory or profibrotic properties. This review makes a strong case for further research focusing on the Gas6/TAM axis as a pharmacological target to manage different disease conditions, such as chronic fibrosis or COVID-19.

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“…Studies have already proposed AXL as a therapeutic target against SARS-CoV-2, as well as its role in cancer [22] , [23] . It has been reported that AXL was highly expressed in lung cancer and significantly increased the infection rate of SARS-Cov-2 in patients [20] .…”

Section: Discussionmentioning

confidence: 99%