At the outset, the design of an organization-based multiagent system is modeled according to the framework of Organization Model for Adaptive Complex Systems (OMACS). Subsequently, this design model is transformed into a process-network model.Eventually, the resultant process-network model in conjunction with the P-graph-based methodology give rise to: (i) the maximal structure of the process network, comprising all the feasible combinations of structures, i.e., OMACS-based design configurations, capable of yielding the specified products from the specified raw material; (ii) every feasible structure for the process of interest; and (iii) the optimal structure of the network, i.e., the optimal OMACS-based design configuration. Finally, in light of the tenet of a modelingtransformation-evaluation paradigm, an appraisal is made of the feasibility as well as the flexibility and cost of the optimal OMACS-based design configuration obtained.