Identifying Features of Early and Late Age-Related Macular Degeneration

Graham, Katie; Chakravarthy, Usha; Hogg, Ruth; Muldrew, K. A.; Young, Ian S.; Kee, Frank

doi:10.1097/iae.0000000000001777

Cited by 51 publications

(34 citation statements)

References 22 publications

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“…MCI has been used to image both superficial and deep retinal and choroidal pathologies. [ 12 13 14 15 19 20 ] Muftuoglu et al . have studied epiretinal membrane with MCI and have concluded that it was visualized better on MCI compared to CFP.…”

Section: Discussionmentioning

confidence: 99%

“…have done a comparative analysis of MCI with CFP in age-related macular degeneration and report the sensitivity of 100% to detect atrophy, hypopigmentation, and fibrosis. [ 14 ] MCI aids in differentiation between true and pseudo optic disc edema by showing greenish hue extending well beyond optic disc margin in former. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

“…MCI has shown promising imaging capabilities in various retinochoroidal diseases such as epiretinal membrane, age-related macular degeneration, and optic disc changes. [ 13 14 15 ] MCI was better in delineating epiretinal membrane than conventional color fundus photography. [ 13 ] It was better in identifying various lesions of posterior segments such as geographic atrophy and optic disc swelling compared to CFP.…”

mentioning

confidence: 99%

“…[ 13 ] It was better in identifying various lesions of posterior segments such as geographic atrophy and optic disc swelling compared to CFP. [ 14 15 ] MCI imaging characteristics of CSC is meagerly reported in literature. He et al .…”

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confidence: 99%

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Validation of multicolor imaging signatures of central serous chorioretinopathy lesions vis-a-vis conventional color fundus photographs

Saurabh

Roy

Goel

et al. 2020

Indian J Ophthalmol

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Purpose: The current study compares the ability of multicolor imaging (MCI) to detect the lesions of central serous chorioretinopathy against conventional color fundus photographs (CFP). Methods: It was a retrospective, observational case series of 93 eyes of 58 patients of central serous chorioretinopathy who underwent MCI and CFP. MCI and spectral-domain optical coherence tomography (SD-OCT) were performed using Spectralis SD-OCT system (HRA + OCT). CFP was obtained using FF 450 Plus fundus camera (Carl Zeiss Meditec, Jena, Germany). SD-OCT was considered gold standard for subretinal fluid (SRF) and retinal pigment epithelium detachment (PED). CFP was considered confirmatory investigation for fibrin and blue autofluorescence image (BAF) was considered gold standard to detect retinal pigment epithelium (RPE) atrophy. Results: CFP could detect SRF in 41 (44.1%) eyes. MCI detected SRF in 43 (46.2%) eyes. The sensitivity and specificity of MCI to detect SRF were 70.7% and 94.3%, respectively. PED was detected by CFP in 21 (22.6%) eyes and MCI in 27 (29%) eyes. The sensitivity and specificity of MCI to detect PED were 70% and 97.7% respectively. CFP could pick RPE atrophy in 52 (55.9%) eyes whereas MCI was picked it in 78 (83.9%) of eyes. Conclusion: Both MCI and CFP were inferior to a gold standard in identifying the SRF, PED, and RPE atrophy. However, MCI was better than CFP in comparison with gold standard for these clinical findings in CSC. Thus, MCI seems to be a more valuable imaging tool compared to CFP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Validation of multicolor imaging signatures of central serous chorioretinopathy lesions vis-a-vis conventional color fundus photographs

Saurabh

Roy

Goel

et al. 2020

Indian J Ophthalmol

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“…There are several studies that compare FAF to fundus cameras [23][24][25][26], confocal scanning laser ophthalmoscope [23][24][25] (cSLO), and spectral--domain optical coherence tomography [27,28] (sd-OCT) as well as studies comparing multicolour imaging to fundus photography [29], but to our knowledge there has been no study comparing FAF to multicolour imaging.…”

Section: Discussionmentioning

confidence: 99%

Fundus autofluorescence and multicolour imaging comparison in assessing disease severity in patients suffering from geographic atrophy. A case series analysis

Mallias

Mylova²,

Tassiopoulou³

2017

Ophthalmology J

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introduCtion. The aim of the study is to determine which depicting modality, fundus autofluorescence or multicolour imaging, is a better diagnostic tool in the monitoring of the progression of geographic atrophy in patients with severe dry macular degeneration. MateriaL and Methods. Fifty patients (93 eyes) participated in this study. OCT examination (Spectralis HRA + OCT, Heidelberg Engineering, Germany) was performed in order to confirm that they fit the criteria to proceed in the study. In all patients, fundus autofluorescence and multicolour imaging was performed. resuLts. The area of geographic atrophy was depicted with both modalities and useful information was obtained. In some cases, multicolour imaging provided more useful clues and in other cases the fundus autofluorescence provided useful information for the progression of the disease. ConCLusions. Both modalities provide a wide range of useful information about the progression of geographic atrophy in patients with severe dry age-related macular degeneration and should both be performed in order to gather all the useful information about the disease progression.

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Efficacy of Multicolor Imaging in Patients With Asteroid Hyalosis

2018

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Asteroid hyalosis is a degenerative change of the vitreous that consists of yellow-white opacities that reflect light and impede the quality of color fundus photography (CFP). 1 Eyes that have retinal disease along with dense asteroid hyalosis usually need spectral-domain optical coherence tomography (SD-OCT) or fluorescein angiography (FA) for adequate assessment of the retina. 2,3 Although SD-OCT and FA do provide information about anatomy of retinal layers and retinal blood vessels, they do not provide information about the spatial distribution of retinal lesions. Multicolor (MC) imaging is a novel imaging technique available with Spectralis SD-OCT (Heidelberg Engineering) that uses 3 different laser lights (blue [488 nm], green [515 nm], and infrared [820 nm]) to create an image of the retina. The blue laser is used to view the vitreoretinal interface and superficial retinal layers. The green laser is used for creating images of the middle retinal layers, including retinal blood vessels, hemorrhages, and exudates. The infrared laser produces images of the outer retinal layers and the choroid. A composite image of these Letters jamaophthalmology.com (Reprinted) JAMA Ophthalmology April 2018 Volume 136, Number 4

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Identifying Features of Early and Late Age-Related Macular Degeneration

Abstract: Multicolor retinal imaging allowed for improved detection and definition of AMD features.

Cited by 51 publications

References 22 publications

Validation of multicolor imaging signatures of central serous chorioretinopathy lesions vis-a-vis conventional color fundus photographs

Validation of multicolor imaging signatures of central serous chorioretinopathy lesions vis-a-vis conventional color fundus photographs

Fundus autofluorescence and multicolour imaging comparison in assessing disease severity in patients suffering from geographic atrophy. A case series analysis

Efficacy of Multicolor Imaging in Patients With Asteroid Hyalosis

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