Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study

Cable, Noriko; Hiyoshi, Ayako; Kondo, Naomi; Aida, Jun; Sjöqvist, Hugo; Kondo, Katsunori

doi:10.1155/2018/5362948

Cited by 15 publications

(16 citation statements)

References 30 publications

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“…HSA has also been assessed to indicate the severity of hepatic diseases in clinical settings . In older people, HSA level is associated with physical frailty and physical function . However, contrary to our expectation, the HSA level was not associated with 6MWD in the present study.…”

Section: Discussioncontrasting

confidence: 99%

“…22 In older people, HSA level is associated with physical frailty and physical function. 23,24 However, contrary to our expectation, the HSA level was not associated with 6MWD in the present study. This might be because of the relatively good nutritional status (prevalence of malnutrition [<17 points] = 0% and risk at malnutrition [17-23.5 points] = 27.3%) and narrow distribution of HSA (mean 4.3 g/dL, standard deviation 0.3 g/dL) in the present study participants.…”

Section: Discussioncontrasting

confidence: 99%

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Association between redox state of human serum albumin and exercise capacity in older women: A cross‐sectional study

Ashikawa

Adachi

Ueyama

et al. 2019

Geriatrics Gerontology Int

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Aim Oxidative stress plays a key role in declining exercise capacity, which is one of the major health problems in old age. The redox state of human serum albumin (HSA) has been considered a biomarker reflecting oxidative stress; however, its relationship to exercise capacity in older people remains to be examined. We aimed to examine the redox state of HSA as a potential biomarker of exercise capacity in community‐dwelling older women. Methods We analyzed 125 women aged ≥75 years. Exercise capacity was evaluated using 6‐min walk distance (6MWD). The redox state of HSA was analyzed using the high‐performance liquid chromatography post‐column bromocresol green reaction method. The fraction of human mercaptalbumin in HSA (f[HMA]) was considered the redox state of HSA. Pearson's correlation coefficient (r) or Spearman's correlation coefficient (ρ) was used to assess correlations between 6MWD, f(HMA) and HSA. The association between 6MWD and f(HMA) was further examined using multivariate linear regression analysis adjusted for age, diabetes mellitus, renal function, number of medications, HSA and knee extensor isometric strength. Results The 6MWD was significantly correlated with f(HMA; ρ = 0.44, P < 0.001), but not with HSA (r = 0.05, P = 0.562). The f(HMA) was not significantly correlated with HSA (ρ = 0.03, P = 0.769). Multivariate linear regression analysis showed that f(HMA) was independently associated with 6MWD (standardized β = 0.27, P = 0.004). Conclusions The findings of this study suggest that f(HMA) might serve as a novel biomarker for exercise capacity in community‐dwelling older women. Geriatr Gerontol Int 2019; ••: ••–••.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Association between redox state of human serum albumin and exercise capacity in older women: A cross‐sectional study

Ashikawa

Adachi

Ueyama

et al. 2019

Geriatrics Gerontology Int

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“…Firstly, our study reported that the median 25(OH)D level of the elderly is 35.89 nmol/L, which is lower than studies reported in Taiwan (40), Netherlands (32), and German (34). Besides, the prevalence of frailty measured by SOF index is 33.2%, which makes a glancing comparison to 13% in the Japanese elderly (16) and 17% in the USA older women(13) by the same screening tool. Since the 25(OH)D level and frailty status are closely related to aging (22), these differences could also be partly explained by the oversampling of octogenarians, nonagenarians, and centenarians in this study.…”

Section: Comparison With Other Studiescontrasting

confidence: 65%

“…The SOF index employed only 3 simple self-reported frailty components (12): muscle strengths, low energy, and unintentional weight loss. It has shown an operational definition to the association with falls, disability, fracture, and death (13,14), and demonstrated the reliability of risk prediction in clinical practice at the population level (12,15,16).…”

mentioning

confidence: 99%

Plasma 25-hydroxyvitamin D level and risk of frailty among Chinese community-based oldest-old: evidence from CLHLS study

Xiao

Cui

et al. 2019

Preprint

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Background: Whether vitamin D deficiency may contribute to frailty remains inconclusive in Chinese older adults. The aim of this study was to examine the association between 25-hydroxyvitamin D [25(OH)D] level and risk of frailty among Chinese oldest-old in the communities.Methods: Secondary analysis of data compiled by the 2011 wave of the Chinese Longitudinal Healthy Longevity Survey (n=1324) was extracted. Frailty was assessed by the Study of Osteoporotic Fractures (SOF) index. Multivariate logistic regression with spine smoothing was performed to investigate the association between 25(OH)D level and risk of frailty after adjusting for sociodemographic variables, health characteristics and confounding biomarkers.Results: The mean age was 92.89 ± 7.92 years, and 844(63.7%) of participants were women. In all, 426 (33.2% , 95% confidence interval, CI: 29.66-34.69) frail participants were recorded. After adjustment for confounding covariates, the level of 25(OH)D is significantly related to frailty. By the spline smoothing and threshold effect analysis , a monotonically negative association between 25(OH)D and frailty was identified. Subgroup analyses revealed that the association did not differ by gender and age . Conclusions: Plasma 25(OH)D was inversely associated with the risk of frailty among Chinese oldestold. The findings indicate the practical significance of monitoring and managing plasma 25(OH)D level in the elders. BackgroundWith the dramatic population aging, growing attention has been given to the aging-related issues.Frailty is defined as a geriatric syndrome representing a reduced ability to re-build homeostasis in response to external stressors during daily life(1). Frailty in the elderly is well established to be related to long-term adverse health outcomes (such as falls, depression, disability, dependency, and mortality) which were not utterly explained by aging, function decline, or comorbidities (2-5).There are two main methods of diagnosing and assessing frailty in existing studies: the Frailty Index and Frailty Phenotype (6-9). The Frailty Index (FI) is based on the comprehensive geriatric assessment (CGA) of overall health decline by the accumulation of deficits in multiple domains(10).

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“…Of existing numerous frailty measures, many often rely on measuring physical function with some being less likely to be readily available in clinical settings and therefore have limited use (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Plasma 25-hydroxyvitamin D level and risk of frailty among Chinese community-based oldest-old: evidence from CLHLS study

Xiao

Cui

et al. 2020

Preprint

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Background: Vitamin D deficiency has been linked to risk of frailty. However, there are limited data for evaluating the potential association of Vitamin D with frailty in a longevous (80+) population. The aim of this study was to examine the association between plasma 25-hydroxyvitamin D [25(OH)D] level and risk of frailty among Chinese oldest-old in the communities. Methods: Secondary analysis of data compiled by the 2011 wave of the Chinese Longitudinal Healthy Longevity Survey (n=1324) was extracted. Frailty was assessed by the Study of Osteoporotic Fractures (SOF) index. Multivariate logistic regression and spine smoothing with threshold effect analysis were performed to investigate the association between 25(OH)D level and risk of frailty after adjusting for socio-demographic variables, health characteristics and confounding biomarkers. Results: The mean age was 92.89 ± 7.92 years, and 844(63.7%) of participants were women. In all, 426 (33.2%, 95% confidence interval, CI: 29.66-34.69) frail participants were recorded . After adjustment for confounding covariates, the level of 25(OH)D was significantly related to frailty. By the spline smoothing with threshold effect analysis, a monotonically negative association between 25(OH)D and frailty was identified. Subgroup analyses revealed that the association did not differ by gender and age. Conclusions : 25(OH)D level was inversely associated with the risk of frailty among the Chinese community-based oldest-old.

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Identifying Frail-Related Biomarkers among Community-Dwelling Older Adults in Japan: A Research Example from the Japanese Gerontological Evaluation Study

Cited by 15 publications

References 30 publications

Association between redox state of human serum albumin and exercise capacity in older women: A cross‐sectional study

Association between redox state of human serum albumin and exercise capacity in older women: A cross‐sectional study

Plasma 25-hydroxyvitamin D level and risk of frailty among Chinese community-based oldest-old: evidence from CLHLS study

Plasma 25-hydroxyvitamin D level and risk of frailty among Chinese community-based oldest-old: evidence from CLHLS study

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