Identifying Individuals at High Risk for Permanent Disability From Depression and Anxiety

Behrens-Wittenberg, Eva; Wedegaertner, F.

doi:10.3389/fpsyt.2020.00740

Cited by 12 publications

(10 citation statements)

References 25 publications

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“…Depression presents a major social, health, and economic concern across the world, representing the number one cause of disability 47 . The root causes of this debilitating disorder have yet to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Stress-Induced Despair Behavior Develops Independently of the AHR-RORgt Axis in CD4+ cells

Rivet-Noor¹,

Merchak²,

Li³

et al. 2022

Preprint

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Current treatments for major depressive disorder are limited to neuropharmacological approaches and are ineffective for large numbers of patients. Recently, alternative means have been explored to understand the etiology of depression. Specifically, changes in the microbiome and immune system have been observed in both clinical settings and in mouse models. As such, microbial supplements and probiotics have become a target for potential therapeutics. A current hypothesis for the mechanism of action of these supplements is via the aryl hydrocarbon receptor’s (AHR) modulation of the T helper 17 cell (Th17) and T regulatory cell axis. As inflammatory RORgt+ CD4+ Th17 T cells and their primary cytokine IL-17 have been implicated in the development of stress-induced depression, the connection between stress, the AHR, Th17s and depression remains critical to disease understanding. Here, we utilize genetic knockouts to examine the role of the microbial sensor AHR in the development of stress induced despair behavior. We observe an AHR-independent increase in gut-associated Th17s in stressed mice, indicating that AHR is not responsible for this communication. Further, we utilized a CD4-specific Rorc knockout line to disrupt the production of Th17s. Mice lacking Rorc induced IL-17 did not show any differences in behavior from controls before or after stress. Finally, we utilize an unsupervised machine learning system to examine minute differences in behavior that could not be observed in traditional behavioral assays. Our data demonstrate that neither CD4 specific Ahr nor Rorc are necessary for the development of stress-induced anxiety-or depressive-like behaviors. These data suggest that research approaches should focus on other sources or sites of IL-17 production in stress-induced depression.

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Section: Discussionmentioning

confidence: 99%

Stress-Induced Despair Behavior Develops Independently of the AHR-RORgt Axis in CD4+ cells

Rivet-Noor¹,

Merchak²,

Li³

et al. 2022

Preprint

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“…The precise interaction between monetary incentive of pensioning and reactivation is still unclear. Previous results suggest that financial security during a period of mental illness is indeed helping rehabilitation, while poverty is associated with a worse outcome (2). Moreover, the quality of the interventions that subjects had received before the time of observation was not evaluated.…”

Section: Limitationsmentioning

confidence: 99%

“…With 19% mental health issues, primarily depression and anxiety, have a high prevalence within the working population (1). They are associated with long sick leave periods (2)(3)(4)(5). Affective disorders are the most common cause of absenteeism from work among all psychiatric illnesses (6).…”

Section: Introductionmentioning

confidence: 99%

A Return-to-Work Intervention for Prematurely Retired Depression or Anxiety Disorder Patients

Behrens-Wittenberg

Wedegaertner

2021

Front. Psychiatry

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Background: Depression and anxiety disorders are the most common cause for premature retirement of people of middle age. These people are expelled from the workforce. The following social disintegration can have an additional detrimental effect on subjects' psychological well-being which further reduces the chance to re-enter the workforce. Depression and anxiety in general need not be regarded as irreversible causes of disability. Therefore, long-term disability should be avoidable in many cases. This two-arm prospective controlled study tests a novel approach for those who have become economically inactive due to their illness with the goal to improve psychological well-being and return to work. Forty-one subjects were followed-up on over a period of 12 months and compared to 41 control cases. ANOVA for repeated measures showed that experimental subjects' psychological well-being and work ability was much better after the intervention than in the control group. These findings show that an individually tailored return-to-work intervention can be a useful therapeutic tool even after retirement.

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“…Some factors are, therefore, expected to have a potential moderating effect on the relationship between visual acuity and health-related quality of life in eye disease patients. It is known that mental health problems can be highly comorbid in eye disease patients 4 , 5 , and that they are likely to deteriorate patients’ health-related quality of life, as depression is in itself an important source of disability 33 , 34 . However, it is still not clear whether mental health outcomes such as symptoms of depression and anxiety can moderate the relationship between visual acuity and health-related quality of life in eye disease patients.…”

Section: Introductionmentioning

confidence: 99%

Anxiety levels moderate the association between visual acuity and health-related quality of life in chronic eye disease patients

Senra

Hernández-Moreno

Moreno³

et al. 2022

Sci Rep

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The current study examines the potential moderating effect of depression and anxiety on the relationship between visual acuity and health-related quality of life in patients with chronic eye diseases. Of the 71 patients, 37 (52%) were female and 34 (48%) were male, age (mean ± SD) was 69 ± 12 years. A significant multivariate regression model was found for patients’ health-related quality of life (EQ-5D-5L index) (R2 = 0.43, p < 0.001), in which visual acuity (logMAR) (p < 0.001), anxiety (HADS-A) (p = 0.007), and age of diagnosis (p = 0.04) were independently associated with health-related quality of life (EQ-5D-5L). The moderation model for anxiety (R2 = 0.47, F = 5.91, p < 0.001) revealed a significant interaction of visual acuity and levels of anxiety in relation to health-related quality of life. Conditional effects analysis suggested that higher logMAR values (which indicate more vision loss) were associated with lower EQ-5D-5L index (indicating worse health-related quality of life), this relationship being stronger (even more negative), when levels of anxiety are high. Clinical and rehabilitation services providing care for chronic eye disease patients should include regular checks for patients’ levels of anxiety, even in patients who still have preserved visual acuity, to help preventing a synergistic source of long-term poor quality of life and disability.

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Identifying Individuals at High Risk for Permanent Disability From Depression and Anxiety

Cited by 12 publications

References 25 publications

Stress-Induced Despair Behavior Develops Independently of the AHR-RORgt Axis in CD4+ cells

Stress-Induced Despair Behavior Develops Independently of the AHR-RORgt Axis in CD4+ cells

A Return-to-Work Intervention for Prematurely Retired Depression or Anxiety Disorder Patients

Anxiety levels moderate the association between visual acuity and health-related quality of life in chronic eye disease patients

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