2017
DOI: 10.1097/md.0000000000007741
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Identifying key genes associated with acute myocardial infarction

Abstract: Background:This study aimed to identify key genes associated with acute myocardial infarction (AMI) by reanalyzing microarray data.Methods:Three gene expression profile datasets GSE66360, GSE34198, and GSE48060 were downloaded from GEO database. After data preprocessing, genes without heterogeneity across different platforms were subjected to differential expression analysis between the AMI group and the control group using metaDE package. P < .05 was used as the cutoff for a differentially expressed gene (DEG… Show more

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Cited by 24 publications
(22 citation statements)
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“…VIP (vasoactive intestinal peptide), cardioprotective in heart failure ( 88 ), and SMAD5 , which has anti-apoptotic actions in cardiac myocytes ( 89 ) were upregulated. On the other hand, AKAP12 , which may protect against IR injury ( 90 ), was downregulated, as were both MYBL2 and TUBB2A , which were recently shown to be upregulated in the heart after acute MI ( 91 , 92 ).…”
Section: Discussionmentioning
confidence: 99%
“…VIP (vasoactive intestinal peptide), cardioprotective in heart failure ( 88 ), and SMAD5 , which has anti-apoptotic actions in cardiac myocytes ( 89 ) were upregulated. On the other hand, AKAP12 , which may protect against IR injury ( 90 ), was downregulated, as were both MYBL2 and TUBB2A , which were recently shown to be upregulated in the heart after acute MI ( 91 , 92 ).…”
Section: Discussionmentioning
confidence: 99%
“…In terms of the cardiovascular diseases, several molecules have already been used as biomarkers, such as the low-E3S Web of Conferences 185, 03039 (2020) ICEEB 2020 http://doi.org/10.1051/e3sconf/202018503039 density lipoprotein cholesterol, circulating brain natriuretic peptide (BNP) and so on [24] . Unfortunately, few of these biomarkers have been currently transformed into practical diagnostic applications [25,26] . With the development of precision medicine and next generation sequencing, miRNAs have shown great advantages in serving as diagnostic and prognostic biomarkers for CADs due to its high specificity, sensitivity and convenient availability [27] .…”
Section: Mirnas Serve As Biomarkers For the Progression Of Cadsmentioning
confidence: 99%
“…Among non-coding RNAs, miRNAs are of particular interest in the context of robustness of biological processes, since they regulate key elements of extensive segments of signaling pathways' networks [8][9][10]. To date, consistency of expressional changes of miRNAs and their target genes has been investigated in macrophages of pigs and rats with experimental MI [11] and in the whole blood of MI patients [12].…”
Section: Introductionmentioning
confidence: 99%