2022
DOI: 10.1136/bmjopen-2021-058383
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Identifying key signs of motor neurone disease in primary care: a nested case–control study using the QResearch database

Abstract: ObjectiveTo confirm the symptoms and signs for motor neuron disease (MND) in the Red Flag tool; to quantify the extent to which the key symptoms and signs are associated with MND; and to identify additional factors which may be helpful within the primary care setting in recognition of possible MND and triggering timely referral to neurology specialists.DesignA nested case–control study.Setting1292 UK general practices contributing to the QResearch primary care database, linked to hospital and mortality data.Pa… Show more

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Cited by 3 publications
(1 citation statement)
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“…The major clinical manifestation of MNDs include progressive muscle weakness and atrophy, muscle fasciculations, spasticity, hyperreflexia, dysphagia, aspiration, dysarthria [4]. Due to severe symptoms and loss of mobility, MND patients require extensive accommodations in surgery.…”
Section: Introductionmentioning
confidence: 99%
“…The major clinical manifestation of MNDs include progressive muscle weakness and atrophy, muscle fasciculations, spasticity, hyperreflexia, dysphagia, aspiration, dysarthria [4]. Due to severe symptoms and loss of mobility, MND patients require extensive accommodations in surgery.…”
Section: Introductionmentioning
confidence: 99%