“…The attempt to include a very large set of information would result in an unfeasible tool and disrupt clinical reasoning. For example, when assessing a single symptom, the formulation of diagnostic hypotheses and/or their rejection can require information regarding the symptom's onset, intensity, duration, P pos , mean positive agreement proportion; P neg , mean negative agreement proportion; Po, total observed agreement proportion a Classified as macular (68/78) or macular-papular (10/78) frequency, quality, context, location, relief, and worsening factors [23]. This kind of essential information cannot be anticipated in a standardized form.…”