2024
DOI: 10.1002/advs.202405818
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Identifying Multiomic Signatures of X‐Linked Retinoschisis‐Derived Retinal Organoids and Mice Harboring Patient‐Specific Mutation Using Spatiotemporal Single‐Cell Transcriptomics

Yueh Chien,
You‐Ren Wu,
Chih‐Ying Chen
et al.

Abstract: X‐linked retinoschisis (XLRS) is an inherited retinal disorder with severe retinoschisis and visual impairments. Multiomics approaches integrate single‐cell RNA‐sequencing (scRNA‐seq) and spatiotemporal transcriptomics (ST) offering potential for dissecting transcriptional networks and revealing cell‐cell interactions involved in biomolecular pathomechanisms. Herein, a multimodal approach is demonstrated combining high‐throughput scRNA‐seq and ST to elucidate XLRS‐specific transcriptomic signatures in two XLRS… Show more

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