Identifying Novel Regulators of Adrenergic Signaling from Endosomes

Abstract

ID 53021 Poster Board 323Physiological responses to catecholamines in many organs, such as the heart, airways, and pancreas, rely on accurate signaling through the beta 2 adrenergic receptor (B2AR), a prototypical G protein-coupled receptor. It is becoming increasingly clear that a complete B2AR physiological response is integrated from many discrete receptor signaling events, separated in time, that originate from different subcellular locations in cells. The spatiotemporal fidelity of these discrete signaling events relies on two critical processes-those that localize receptors to specific compartments, and those that ensure that the receptors couple to the correct signaling components in these compartments. The biochemical networks that mediate these processes, however, are still not fully understood.