Antibiotic allergy labelling is highly prevalent and negatively impacts patient outcomes and antibiotic appropriateness. Reducing the prevalence and burden of antibiotic allergies requires the engagement of key stakeholders such as allergists, immunologists, pharmacists and infectious diseases physicians. To help address this burden of antibiotic allergy over-labelling, we review three key antibiotic allergy domains: (a) antibiotic allergy classification, (b) antibiotic cross-reactivity and (c) multidisciplinary collaboration. We review the available evidence and research gaps of currently utilized adverse drug reaction (ADR) classification systems, antibiotic allergy cross-reactivity and current and future models of antibiotic allergy care.