“…We view the SSP*RCP framework as a promising tool to explore the complex interactions among socioeconomic development, climate change, and the future spread of VBDs -as recently highlighted in Messina et al (2019). The main advantages of this framework include (i) the SSPs are being increasingly quantified (on gridded scales) for a number of relevant variables such as population growth (Jones & O'Neill, 2016, Gao, 2017, GDP (Murakami & Yamagata, 2016, Gidden, In review), and urbanization (Gao & O'Neill, 2019, (ii) the scenarios account for the wide range of uncertainties in both socioeconomic development type and emission scenarios, (iii) the scenario matrix can be used to explore the relative contribution of climate change and socioeconomic development to the future spread of VBDs, and (iv) the growing literature on the vulnerability of populations -and of the health sector -under the SSPs (Ebi, 2013, Sellers & Ebi, 2017, Rao et al, 2018, Zimm et al, 2018, Welborn, 2018, Striessnig & Loichinger, 2016 can inform about the future vulnerability of exposed populations.…”